RELA and PLK1

Data Source:
BioGRID (pull down)

		RELA	PLK1
Description		RELA proto-oncogene, NF-kB subunit	polo like kinase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol NF-kappaB P50/p65 Complex Glutamatergic Synapse	Kinetochore Chromatin Synaptonemal Complex Spindle Pole Condensed Nuclear Chromosome Outer Kinetochore Nucleus Nucleoplasm Cytoplasm Centrosome Centriole Spindle Cytosol Spindle Microtubule Microtubule Cytoskeleton Midbody Centriolar Satellite Spindle Midzone Mitotic Spindle Pole
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Peptide Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Actinin Binding Histone Deacetylase Binding Protein-containing Complex Binding Protein N-terminus Binding NF-kappaB Binding Repressing Transcription Factor Binding Ankyrin Repeat Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Anaphase-promoting Complex Binding Kinase Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Hair Follicle Development Stimulatory C-type Lectin Receptor Signaling Pathway Acetaldehyde Metabolic Process Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cellular Defense Response I-kappaB Kinase/NF-kappaB Signaling Aging Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Response To Organic Substance Response To UV-B Positive Regulation Of Schwann Cell Differentiation Viral Process Cytokine-mediated Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Response To Progesterone Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-8 Production Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Protein Sumoylation Cellular Response To Stress Response To Cobalamin Response To Cytokine Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Muscle Stretch NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Morphine Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Response To CAMP Defense Response To Virus Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Postsynapse To Nucleus Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Angiotensin Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Cytokinesis Microtubule Bundle Formation Protein Phosphorylation Ubiquitin-dependent Protein Catabolic Process Sister Chromatid Cohesion Mitotic Nuclear Envelope Disassembly Mitotic Spindle Assembly Checkpoint Centrosome Cycle Regulation Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Peptidyl-threonine Phosphorylation Female Meiosis Chromosome Segregation Protein Ubiquitination Peptidyl-serine Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Anaphase-promoting Complex-dependent Catabolic Process Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Regulation Of Protein Binding Homologous Chromosome Segregation Establishment Of Protein Localization Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Proteolysis Nuclear Envelope Disassembly Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Synaptonemal Complex Disassembly Protein Localization To Chromatin Signal Transduction Involved In G2 DNA Damage Checkpoint Protein Localization To Nuclear Envelope Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Nucleus Regulation Of Mitotic Spindle Assembly Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Protein Localization To Cell Cortex
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Phosphorylation of the APC/C Phosphorylation of Emi1 Condensation of Prophase Chromosomes Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Activation of NIMA Kinases NEK9, NEK6, NEK7 Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase Mitotic Metaphase/Anaphase Transition Mitotic Telophase/Cytokinesis Cyclin A/B1/B2 associated events during G2/M transition The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Drugs		Dimethyl fumarate SC-236	3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol 3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE 1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea Wortmannin Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31619474) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Sensation seeking ( 30718321) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Urate levels ( 31985003 31578528)	Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494)
Interacting Genes		203 interacting genes: AATF ACTL6A AGO1 AHR AKAP8 APBA2 AR ARNT ASB9 AURKA BANP BATF2 BRCA1 BRMS1 BTK BTRC C1QB CALM1 CAMK4 CARM1 CCL5 CCND2 CDC34 CDK9 CEBPB CEBPD CHEK1 CHUK CNNM3 COL2A1 COMMD1 CREBBP CSNK1G1 CSNK2A1 CSNK2A2 DDC DDX1 DHX9 DNAJA3 DNMT3L ECSIT EEF1D EGR1 EP300 EPHA2 ESR1 ETHE1 EZH2 FAF1 FKBP11 FOS FUS GLIS1 GOPC GTF2B HDAC1 HDAC2 HDAC3 HEXIM1 HMGA2 HMGB1 HSPA4 IGF1R IKBKB IKBKE IKBKG ING4 IRAK1BP1 IRF1 IRF2 IRF3 IRF8 IRF9 ISL1 JUN KAT2A KAT2B KAT5 KDM2A KEAP1 KPNA2 LATS2 LMO2 MAP2K6 MAP3K7 MAP3K8 MAPK10 MAPK14 MED15 MED23 MED7 MEN1 MEOX2 MKRN2 MST1R MTPN MX1 MYC NCOA3 NCOA6 NCOR2 NFIC NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NKRF NKX2-1 NOTCH1 NPM1 NR3C1 PARP1 PDCD11 PGR PIAS1 PIAS3 PIK3CA PIN1 PKM PLA2G4A PLK1 PML POU2F1 POU6F2 PPARA PPARG PPP1R13L PPP2CA PPP2CB PPP2R1B PPP4C PRKACA PRKCZ PRMT1 PRTN3 PSMD10 RAD51 RASSF1 REL RELB REPS2 RFC1 RIOK2 RNASE1 RNF25 RPL13 RPL23 RPS3 RPS6KA5 RTN4IP1 RXRA SAT1 SETD7 SIN3A SIRT1 SMAD3 SMAD4 SNIP1 SNRNP70 SOCS1 SOCS6 SORD SP1 SRF STAT1 STAT3 STAT6 SUOX TAF1 TAF11 TAF4B TAF6 TAF9 TBK1 TBP TCAP TCF4 TERT TGM2 TLE5 TNIP2 TP53 TP53BP1 TP53BP2 TRIB3 TRIM55 TRIM63 TRIP4 TSC22D3 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2L3 UNC5CL USF2 USP7 ZBTB7A ZBTB7B	120 interacting genes: - ACTL6B APP ASPM BAG6 BCL2L1 BIRC6 BRCA2 BUB1 BUB1B C6orf136 CCDC115 CCNB1 CDC14A CDC25C CENPQ CEP55 CHEK2 CSN1S1 CSN2 CTNNB1 DNAJB9 DNHD1 ECT2 EIF6 FBXL5 FBXW7 FZR1 GET4 GLB1 GORASP1 IKBKB INTS11 ITSN1 KIF23 KIF2C KLF4 KLHL22 KRBA1 LMO4 LRP5L LRRK1 LRRK2 MAD2L1BP MAGED1 MCM2 MCM3 MCM7 MDM2 MPP2 MYC MYT1 NEDD4 NHSL2 NINL NPM1 NUDC PARP10 PHC2 PIN1 PITPNM1 PKMYT1 PLK3 PPID PRC1 PRKN PSMA1 PSMA3 PSMA4 PSMA5 PSMA6 PSMA7 PSMB1 PSMB2 PSMB3 PSMB4 PSMB5 PSMB6 PSMB7 PTEN PTPRD RABAC1 RACGAP1 RAD51 RAP1GAP RECQL5 RELA REST RGCC RICTOR RNF126 RNF2 RXRA SIMC1 SNCA SNCB SPOUT1 SREBF1 STAG2 STK3 STUB1 SUGT1 TANK TNFSF11 TOP2A TP53 TP53BP2 TP73 TPT1 TRIOBP TSC1 TUBA4A TUBB TUBB3 TUBG1 USP16 USP7 VRK3 WEE1 ZNF71
Entrez ID		5970	5347
HPRD ID		01241	03652
Ensembl ID		ENSG00000173039	ENSG00000166851
Uniprot IDs		A0A087X0W8 Q04206	P53350
PDB IDs		1NFI 2LSP 2O61 3GUT 3QXY 3RC0 4KV1 4KV4 5U4K 5URN 6NV2 6QHL 6QHM 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2	1Q4K 1Q4O 1UMW 2OGQ 2OJX 2OU7 2OWB 2RKU 2V5Q 2YAC 3BZI 3C5L 3FC2 3FVH 3HIH 3HIK 3KB7 3P2W 3P2Z 3P34 3P35 3P36 3P37 3Q1I 3RQ7 3THB 4A4L 4A4O 4DFW 4E67 4E9C 4E9D 4H5X 4H71 4HAB 4HCO 4HY2 4J52 4J53 4LKL 4LKM 4O56 4O6W 4O9W 4RCP 4WHH 4WHK 4WHL 4X9R 4X9V 4X9W 5J19 5NEI 5NFU 5NJE 5NMM 5NN1 5NN2 5TA6 5TA8 6AX4 6GY2
Enriched GO Terms of Interacting Partners?
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