RELA and IRF3

Data Source:
HPRD (in vivo)

		RELA	IRF3
Description		RELA proto-oncogene, NF-kB subunit	interferon regulatory factor 3
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Cytosol NF-kappaB P50/p65 Complex Glutamatergic Synapse	Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enzyme Binding Protein Kinase Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Peptide Binding Phosphate Ion Binding Identical Protein Binding Protein Homodimerization Activity Actinin Binding Histone Deacetylase Binding Protein-containing Complex Binding Protein N-terminus Binding NF-kappaB Binding Repressing Transcription Factor Binding Ankyrin Repeat Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Hair Follicle Development Stimulatory C-type Lectin Receptor Signaling Pathway Acetaldehyde Metabolic Process Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Inflammatory Response Cellular Defense Response I-kappaB Kinase/NF-kappaB Signaling Aging Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Response To Organic Substance Response To UV-B Positive Regulation Of Schwann Cell Differentiation Viral Process Cytokine-mediated Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Type I Interferon Production Response To Muramyl Dipeptide Response To Progesterone Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-8 Production Response To Insulin Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Protein Sumoylation Cellular Response To Stress Response To Cobalamin Response To Cytokine Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Vascular Endothelial Growth Factor Stimulus Response To Muscle Stretch NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Response To Drug Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Morphine Regulation Of DNA-templated Transcription In Response To Stress Innate Immune Response Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Response To CAMP Defense Response To Virus Cellular Response To Hydrogen Peroxide Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Postsynapse To Nucleus Signaling Pathway Regulation Of NIK/NF-kappaB Signaling Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Angiotensin Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of MiRNA Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription By RNA Polymerase II Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Lipopolysaccharide-mediated Signaling Pathway Regulation Of Type I Interferon Production Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death Cellular Response To Virus
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection	ISG15 antiviral mechanism IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN Interferon gamma signaling TICAM1-dependent activation of IRF3/IRF7 Interferon alpha/beta signaling TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Negative regulators of DDX58/IFIH1 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
Drugs		Dimethyl fumarate SC-236
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31619474) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Inflammatory bowel disease ( 23128233) LDL cholesterol levels ( 32203549) Sensation seeking ( 30718321) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Urate levels ( 31985003 31578528)	Autoimmune thyroid disease ( 32581359) Schizophrenia ( 29483656) Vitiligo ( 27723757)
Interacting Genes		203 interacting genes: AATF ACTL6A AGO1 AHR AKAP8 APBA2 AR ARNT ASB9 AURKA BANP BATF2 BRCA1 BRMS1 BTK BTRC C1QB CALM1 CAMK4 CARM1 CCL5 CCND2 CDC34 CDK9 CEBPB CEBPD CHEK1 CHUK CNNM3 COL2A1 COMMD1 CREBBP CSNK1G1 CSNK2A1 CSNK2A2 DDC DDX1 DHX9 DNAJA3 DNMT3L ECSIT EEF1D EGR1 EP300 EPHA2 ESR1 ETHE1 EZH2 FAF1 FKBP11 FOS FUS GLIS1 GOPC GTF2B HDAC1 HDAC2 HDAC3 HEXIM1 HMGA2 HMGB1 HSPA4 IGF1R IKBKB IKBKE IKBKG ING4 IRAK1BP1 IRF1 IRF2 IRF3 IRF8 IRF9 ISL1 JUN KAT2A KAT2B KAT5 KDM2A KEAP1 KPNA2 LATS2 LMO2 MAP2K6 MAP3K7 MAP3K8 MAPK10 MAPK14 MED15 MED23 MED7 MEN1 MEOX2 MKRN2 MST1R MTPN MX1 MYC NCOA3 NCOA6 NCOR2 NFIC NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NKRF NKX2-1 NOTCH1 NPM1 NR3C1 PARP1 PDCD11 PGR PIAS1 PIAS3 PIK3CA PIN1 PKM PLA2G4A PLK1 PML POU2F1 POU6F2 PPARA PPARG PPP1R13L PPP2CA PPP2CB PPP2R1B PPP4C PRKACA PRKCZ PRMT1 PRTN3 PSMD10 RAD51 RASSF1 REL RELB REPS2 RFC1 RIOK2 RNASE1 RNF25 RPL13 RPL23 RPS3 RPS6KA5 RTN4IP1 RXRA SAT1 SETD7 SIN3A SIRT1 SMAD3 SMAD4 SNIP1 SNRNP70 SOCS1 SOCS6 SORD SP1 SRF STAT1 STAT3 STAT6 SUOX TAF1 TAF11 TAF4B TAF6 TAF9 TBK1 TBP TCAP TCF4 TERT TGM2 TLE5 TNIP2 TP53 TP53BP1 TP53BP2 TRIB3 TRIM55 TRIM63 TRIP4 TSC22D3 TWIST1 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H UBE2L3 UNC5CL USF2 USP7 ZBTB7A ZBTB7B	30 interacting genes: CREBBP EP300 EWSR1 FBXO7 GRIP1 HERC5 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70 TRIM26 TRIM55 TRIM63
Entrez ID		5970	3661
HPRD ID		01241	04769
Ensembl ID		ENSG00000173039	ENSG00000126456
Uniprot IDs		A0A087X0W8 Q04206	E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653
PDB IDs		1NFI 2LSP 2O61 3GUT 3QXY 3RC0 4KV1 4KV4 5U4K 5URN 6NV2 6QHL 6QHM 6YOW 6YOX 6YOY 6YP2 6YP3 6YP8 6YPL 6YPY 6YQ2	1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6 5JEJ 5JEK 5JEL 5JEM 5JEO 5JER 6SIV 6SJA 7JFL
Enriched GO Terms of Interacting Partners?
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