SPINK7 and FTL

Data Source:
BioGRID (two hybrid)

		SPINK7	FTL
Description		serine peptidase inhibitor Kazal type 7	ferritin light chain
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GO Annotations	Cellular Component	Extracellular Region	Extracellular Region Cytoplasm Cytosol Intracellular Ferritin Complex Membrane Azurophil Granule Lumen Autolysosome Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Endopeptidase Activity	Iron Ion Transport Cellular Iron Ion Homeostasis Intracellular Sequestering Of Iron Ion Neutrophil Degranulation Iron Ion Homeostasis
Pathways			Scavenging by Class A Receptors Golgi Associated Vesicle Biogenesis Neutrophil degranulation Iron uptake and transport
Drugs			Iron Dextran Protoporphyrin Ferric pyrophosphate Sodium ferric gluconate complex Ferric pyrophosphate citrate
Diseases			Neurodegeneration with brain iron accumulation (NBIA); Hallervorden-Spatz syndrome; Neuroferritinopathy; Aceruloplasminemia
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382)
Interacting Genes		8 interacting genes: EPB42 FTL HBA1 MRPS12 MT1G MT1H MT2A RABL6	29 interacting genes: CLEC4G FTH1 GADD45A GLP1R GRB2 HTT IGDCC3 KNG1 KPNA3 MAP3K12 MEOX2 MPHOSPH6 MTNR1B MYOC MYOG NTAQ1 PALS2 PIK3CA PPP1CC PTN RAP2A SDCBP SLC13A1 SMAD9 SPINK7 TAF10 USHBP1 VKORC1 ZDHHC17
Entrez ID		84651	2512
HPRD ID		16850	00616
Ensembl ID		ENSG00000145879	ENSG00000087086
Uniprot IDs		P58062	A0A384MDR3 P02792
PDB IDs		2LEO	2FFX 2FG4 2FG8 3KXU 4V6B 5LG8 6TR9 6TS0 6TS1 6TSA 6TSF 6TSJ 6WX6
Enriched GO Terms of Interacting Partners?
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