FOXN1 and CDA

Data Source:
BioGRID (two hybrid)

		FOXN1	CDA
Description		forkhead box N1	cytidine deaminase
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GO Annotations	Cellular Component	Chromatin Nucleus	Extracellular Region Cytosol Secretory Granule Lumen Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding	Nucleoside Binding Cytidine Deaminase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Hair Follicle Development T Cell Lineage Commitment Regulation Of Transcription By RNA Polymerase II Defense Response Epidermis Development Animal Organ Morphogenesis Keratinocyte Differentiation Positive Regulation Of Epithelial Cell Differentiation Nail Development T Cell Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Positive Regulation Of Hair Follicle Development Lymphoid Lineage Cell Migration Into Thymus Thymus Epithelium Morphogenesis Regulation Of Positive Thymic T Cell Selection	Cell Surface Receptor Signaling Pathway Pyrimidine-containing Compound Salvage Cytidine Deamination Cytosine Metabolic Process Negative Regulation Of Cell Growth Pyrimidine Nucleoside Salvage Neutrophil Degranulation Negative Regulation Of Nucleotide Metabolic Process
Pathways			Neutrophil degranulation Pyrimidine salvage
Drugs			1-Beta-Ribofuranosyl-1,3-Diazepinone Cedazuridine
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Bone mineral density ( 31790847) Metabolite levels ( 31628463) Tonsillectomy ( 27182965 28928442)	Apolipoprotein A1 levels ( 32203549) Basophil percentage of white cells ( 32888494) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Proportion of activated microglia (inferior temporal cortex) ( 30679421) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		12 interacting genes: CDA CDC23 DMRT3 HOXA1 LHX8 MAPKBP1 PIN1 SPATC1L TLE5 TRAF2 TRAPPC6A TSSK1B	18 interacting genes: ADAT3 ARRDC3 DDIT4L FNDC11 FOXN1 GORASP2 INCA1 KPNA2 KRTAP6-1 KRTAP8-1 LNX1 NTAQ1 PLEKHB2 PSMA1 PTGER3 SDCBP ZBTB24 ZNF598
Entrez ID		8456	978
HPRD ID		02907	11744
Ensembl ID		ENSG00000109101	ENSG00000158825
Uniprot IDs		O15353	P32320
PDB IDs		5OCN 6EL8	1MQ0
Enriched GO Terms of Interacting Partners?
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