SENP8 and CUL2

Data Source:
BioGRID (enzymatic study)

		SENP8	CUL2
Description		SUMO peptidase family member, NEDD8 specific	cullin 2
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GO Annotations	Cellular Component	Cytosol	Nucleoplasm Cytosol SCF Ubiquitin Ligase Complex VCB Complex Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding NEDD8-specific Protease Activity	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding
	Biological Process	Protein Deubiquitination Post-translational Protein Modification	G1/S Transition Of Mitotic Cell Cycle Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Intrinsic Apoptotic Signaling Pathway
Pathways		UCH proteinases Neddylation	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Neddylation Regulation of expression of SLITs and ROBOs Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Metabolite levels (HVA/MHPG ratio) ( 23319000)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28	25 interacting genes: ARID1B CAND1 CDC34 COMMD1 COPS5 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 E2F1 ELOC GPS1 KAT2A KHNYN MKNK2 NEDD8 RBX1 RNF7 SAP130 SENP8 UBC UBE2D1 VHL ZER1 ZYG11B
Entrez ID		123228	8453
HPRD ID		09784	06786
Ensembl ID		ENSG00000166192	ENSG00000108094
Uniprot IDs		A8K8D3 Q96LD8	A0A0A0MTN0 A0A140VKB1 B7Z1Y1 Q13617
PDB IDs		1XT9 2BKQ 2BKR	4WQO 5N4W 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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