SENP8 and NEDD8

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		SENP8	NEDD8
Description		SUMO peptidase family member, NEDD8 specific	NEDD8 ubiquitin like modifier
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GO Annotations	Cellular Component	Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding NEDD8-specific Protease Activity	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding
	Biological Process	Protein Deubiquitination Post-translational Protein Modification	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Iron Ion Homeostasis Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Protein Deubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Post-translational Protein Modification Protein Neddylation
Pathways		UCH proteinases Neddylation	TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport
Drugs
Diseases
GWAS		Metabolite levels (HVA/MHPG ratio) ( 23319000)	Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)
Interacting Genes		15 interacting genes: CHN2 COPS2 CUL1 CUL2 CUL4A GPS1 HSPA4 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28	42 interacting genes: AHR ARIH2 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A HSPA4 N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2
Entrez ID		123228	4738
HPRD ID		09784	04412
Ensembl ID		ENSG00000166192	ENSG00000129559
Uniprot IDs		A8K8D3 Q96LD8	Q15843
PDB IDs		1XT9 2BKQ 2BKR	1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU
Enriched GO Terms of Interacting Partners?
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