DCTN5 and PMEPA1

Data Source:
BioGRID (two hybrid, pull down)

		DCTN5	PMEPA1
Description		dynactin subunit 5	prostate transmembrane protein, androgen induced 1
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleoplasm Centrosome Cytosol Nuclear Membrane	Golgi Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Binding WW Domain Binding R-SMAD Binding
	Biological Process	Ventricular Septum Development Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Aorta Development Coronary Vasculature Development	Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic	Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 17554300)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		5 interacting genes: DYNLL1 FATE1 NINL PMEPA1 RBPMS	11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4
Entrez ID		84516	56937
HPRD ID		14551	09415
Ensembl ID		ENSG00000166847	ENSG00000124225
Uniprot IDs		Q9BTE1	Q5JY37 Q969W9
PDB IDs		5NW4
Enriched GO Terms of Interacting Partners?
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