PMEPA1 and STAM

Data Source:
BioGRID (pull down)

		PMEPA1	STAM
Description		prostate transmembrane protein, androgen induced 1	signal transducing adaptor molecule
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle	Cytosol Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding WW Domain Binding R-SMAD Binding	Protein Binding Ubiquitin-like Protein Ligase Binding
	Biological Process	Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Signal Transduction Endosomal Transport Macroautophagy Protein Deubiquitination Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly
Pathways		Downregulation of TGF-beta receptor signaling	EGFR downregulation Metalloprotease DUBs Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT)
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4	20 interacting genes: ARRB1 HGS JAK1 JAK2 JAK3 MAP3K1 PJA1 PMEPA1 PPP1CA PPP1CC RFFL STAMBP TIMM8A TRIM54 TRIM55 TRIM63 UBC USP15 USP28 USP8
Entrez ID		56937	8027
HPRD ID		09415	03542
Ensembl ID		ENSG00000124225	ENSG00000136738
Uniprot IDs		Q5JY37 Q969W9	B4DZT2 Q92783
PDB IDs			2L0A 3F1I 3LDZ
Enriched GO Terms of Interacting Partners?
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