PMEPA1 and DCTN5

Data Source:
BioGRID (two hybrid, pull down)

		PMEPA1	DCTN5
Description		prostate transmembrane protein, androgen induced 1	dynactin subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle	Condensed Chromosome Kinetochore Nucleoplasm Centrosome Cytosol Nuclear Membrane
	Molecular Function	Protein Binding WW Domain Binding R-SMAD Binding	Protein Binding
	Biological Process	Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation	Ventricular Septum Development Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Aorta Development Coronary Vasculature Development
Pathways		Downregulation of TGF-beta receptor signaling	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS		Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075)	Bipolar disorder ( 17554300)
Interacting Genes		11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4	5 interacting genes: DYNLL1 FATE1 NINL PMEPA1 RBPMS
Entrez ID		56937	84516
HPRD ID		09415	14551
Ensembl ID		ENSG00000124225	ENSG00000166847
Uniprot IDs		Q5JY37 Q969W9	Q9BTE1
PDB IDs			5NW4
Enriched GO Terms of Interacting Partners?
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