FBN3 and RPS6KA6

Data Source:
BioGRID (two hybrid)

		FBN3	RPS6KA6
Description		fibrillin 3	ribosomal protein S6 kinase A6
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Matrix Collagen-containing Extracellular Matrix	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Anatomical Structure Morphogenesis	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development
Pathways		Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres	Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation
Drugs		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate	Fostamatinib
Diseases
GWAS		Attention deficit hyperactivity disorder ( 30563984) Blood protein levels ( 28240269) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Pre-treatment viral load in HIV-1 infection ( 31219150) Refractive error ( 32231278) Serum metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		13 interacting genes: ANXA7 BID C11orf58 CDKN1A DAZAP2 GADD45A GSK3B NUDT21 PIK3R3 RPN2 RPS6KA6 TK1 TSC22D1	28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746
Entrez ID		84467	27330
HPRD ID		10538	02250
Ensembl ID		ENSG00000142449	ENSG00000072133
Uniprot IDs		A0A494C0D8 A8KAY2 Q75N90	Q9UK32
PDB IDs			6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?
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