RPS6KA6 and DNAJC13

Data Source:
BioGRID (two hybrid)

		RPS6KA6	DNAJC13
Description		ribosomal protein S6 kinase A6	DnaJ heat shock protein family (Hsp40) member C13
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol	Lysosomal Membrane Cytosol Plasma Membrane Endosome Membrane Membrane Secretory Granule Membrane Early Endosome Membrane Azurophil Granule Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome WASH Complex
	Molecular Function	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Binding
	Biological Process	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development	Osteoblast Differentiation Receptor-mediated Endocytosis Endosome Organization Protein Transport Neutrophil Degranulation Regulation Of Early Endosome To Recycling Endosome Transport Regulation Of Early Endosome To Late Endosome Transport
Pathways		Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation	Neutrophil degranulation
Drugs		Fostamatinib
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Iron status biomarkers (total iron binding capacity) ( 28334935) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Neutrophil count ( 32888494) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Total cholesterol levels ( 30275531) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		28 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPRED2 SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746	6 interacting genes: CALM1 CLK1 DNAJB11 GADD45A GSK3B RPS6KA6
Entrez ID		27330	23317
HPRD ID		02250	10915
Ensembl ID		ENSG00000072133	ENSG00000138246
Uniprot IDs		Q9UK32	B3KN02 O75165
PDB IDs		6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?
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