ZNF414 and SH2B2

Data Source:
BioGRID (two hybrid)

		ZNF414	SH2B2
Description		zinc finger protein 414	SH2B adaptor protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Blood Coagulation Insulin Receptor Signaling Pathway Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway B Cell Receptor Signaling Pathway
Pathways			Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Type 2 diabetes ( 31049640)
Interacting Genes		54 interacting genes: ADAMTSL4 CALCOCO2 CARD10 CFP CNFN CYSRT1 FBLN2 GOLGA2 GOLGA6L9 HOMER3 ITIH6 KANK2 KRT31 KRT34 KRT36 KRT86 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP13-3 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP3-1 KRTAP4-12 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP6-3 KRTAP9-3 MDFI MGAT5B MKRN3 MTUS2 NBPF19 NOTCH2NLA PDE4DIP PICK1 POU2AF1 PPP1R16A RBCK1 RBM11 RNF125 SH2B2 SORBS3 SPRED2 TERF2IP TEX11 TLE5 TRIM10 TRIM27 TRIM42 WWOX ZMYND12	42 interacting genes: AKT1 ASB6 BTK CBL CLK1 CLK3 DUSP13 EGFR EPOR ERBB2 ERBB4 FAM124B FAM90A1 FYN GRB2 HCK IL36RN INSR JAK1 JAK2 JAK3 KIT LMO3 LYN MAGEH1 MCRS1 MET MTDH NTRK1 NTRK2 PDLIM7 PLEKHA3 RAB6B SH2B1 SHC1 SORBS1 SYK TLE5 TLNRD1 USP2 ZNF414 ZNF417
Entrez ID		84330	10603
HPRD ID		17511	16097
Ensembl ID		ENSG00000133250	ENSG00000160999
Uniprot IDs		Q96IQ9	O14492
PDB IDs			1Q2H
Enriched GO Terms of Interacting Partners?
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