NR0B2 and PAX9

Data Source:
BioGRID (two hybrid)

		NR0B2	PAX9
Description		nuclear receptor subfamily 0 group B member 2	paired box 9
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Protein-containing Complex	Chromatin Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Homodimerization Activity Peroxisome Proliferator Activated Receptor Binding Protein-containing Complex Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Transcription Regulator Inhibitor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Circadian Rhythm Cholesterol Metabolic Process Response To Glucose Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Response To Organic Cyclic Compound Bile Acid And Bile Salt Transport Animal Organ Regeneration Positive Regulation Of Insulin Secretion Circadian Regulation Of Gene Expression Negative Regulation Of DNA-binding Transcription Factor Activity Response To Ethanol Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated	Regulation Of Transcription By RNA Polymerase II Endoderm Development Odontogenesis Regulation Of Odontogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development Face Morphogenesis Cellular Response To Growth Factor Stimulus
Pathways		Nuclear Receptor transcription pathway
Drugs
Diseases			Tooth agenesis; Hypodontia
GWAS		Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) HDL cholesterol ( 24097068) LDL cholesterol ( 24097068) Triglycerides ( 24097068)	Breast cancer ( 29059683 23535729) Height ( 28552196) Lobe attachment (rater scored) ( 29198719) Lobe attachment (rater-scored or self-reported) ( 29198719) Nonsyndromic cleft palate ( 31609978) Prostate cancer ( 29892016)
Interacting Genes		51 interacting genes: AR CHRD CIDEC DDX20 EID1 ESR1 ESR2 ESRRA ESRRG FN1 GPS2 GPSM3 HDAC3 HDAC6 HNF4A HNF4G HNRNPA1 ID2 IL3RA NCOA3 NEUROD1 NR1H2 NR1H3 NR1I2 NR1I3 NR3C1 NR5A2 PAX9 PEF1 PLSCR1 POLR2A PPARD PPARG RARA RARG RBP5 RNF31 RXRA RXRB RXRG SMAD4 SMARCA2 SMARCB1 SMARCE1 SNW1 THRA TP53 VDR XBP1 ZAP70 ZMYND10	26 interacting genes: EYA2 FUBP3 GTF2A1L KDM5B KLF4 KRTAP13-3 LMO2 MSX1 MYLIP NR0B2 PFDN5 PLAGL2 SFN SLAIN1 SSX4 TEPSIN TLE1 TLE2 TLE5 TRIP13 TRIP4 VPS37C WWOX ZNF343 ZNF440 ZNF580
Entrez ID		8431	5083
HPRD ID		05219	01336
Ensembl ID		ENSG00000131910	ENSG00000198807
Uniprot IDs		Q15466	P55771 Q2L4T1
PDB IDs		1YUC 2Q3Y 2Z4J 4DOR 4ONI 5UFS 6W9M
Enriched GO Terms of Interacting Partners?
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