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NR0B2 and HDAC6
Data Source:
BioGRID
(pull down)
NR0B2
HDAC6
Description
nuclear receptor subfamily 0 group B member 2
histone deacetylase 6
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Protein-containing Complex
Histone Deacetylase Complex
Nucleus
Nucleoplasm
Cytoplasm
Multivesicular Body
Cytosol
Microtubule
Microtubule Associated Complex
Caveola
Inclusion Body
Aggresome
Dynein Complex
Axon
Dendrite
Cell Leading Edge
Perikaryon
Perinuclear Region Of Cytoplasm
Molecular Function
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Protein Domain Specific Binding
Protein Homodimerization Activity
Peroxisome Proliferator Activated Receptor Binding
Protein-containing Complex Binding
Retinoid X Receptor Binding
Thyroid Hormone Receptor Binding
Transcription Regulator Inhibitor Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Corepressor Binding
Actin Binding
Histone Deacetylase Activity
Protein Binding
Beta-catenin Binding
Microtubule Binding
Zinc Ion Binding
Enzyme Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
NAD-dependent Histone Deacetylase Activity (H3-K14 Specific)
Protein Deacetylase Activity
Histone Deacetylase Binding
Tubulin Deacetylase Activity
Alpha-tubulin Binding
Ubiquitin Binding
Acetylspermidine Deacetylase Activity
Tau Protein Binding
Beta-tubulin Binding
Misfolded Protein Binding
Hsp90 Protein Binding
Dynein Complex Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Notch Signaling Pathway
Circadian Rhythm
Cholesterol Metabolic Process
Response To Glucose
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Response To Organic Cyclic Compound
Bile Acid And Bile Salt Transport
Animal Organ Regeneration
Positive Regulation Of Insulin Secretion
Circadian Regulation Of Gene Expression
Negative Regulation Of DNA-binding Transcription Factor Activity
Response To Ethanol
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Protein Polyubiquitination
Protein Deacetylation
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Intracellular Protein Transport
Autophagy
Negative Regulation Of Microtubule Depolymerization
Regulation Of Autophagy
Positive Regulation Of Epithelial Cell Migration
Negative Regulation Of Hydrogen Peroxide Metabolic Process
Regulation Of Macroautophagy
Histone Deacetylation
Negative Regulation Of Protein-containing Complex Assembly
Regulation Of Protein Stability
Protein Destabilization
Lysosome Localization
Protein-containing Complex Disassembly
Positive Regulation Of Peptidyl-serine Phosphorylation
Peptidyl-lysine Deacetylation
Cellular Response To Topologically Incorrect Protein
Regulation Of Gene Expression, Epigenetic
Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway
Negative Regulation Of Protein-containing Complex Disassembly
Regulation Of Fat Cell Differentiation
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Collateral Sprouting
Negative Regulation Of Oxidoreductase Activity
Mitochondrion Localization
Response To Misfolded Protein
Cilium Assembly
Regulation Of Microtubule-based Movement
Regulation Of Androgen Receptor Signaling Pathway
Dendritic Spine Morphogenesis
Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization
Regulation Of Establishment Of Protein Localization
Cellular Response To Hydrogen Peroxide
Aggresome Assembly
Polyubiquitinated Misfolded Protein Transport
Hsp90 Deacetylation
Response To Growth Factor
Histone H3 Deacetylation
Cellular Response To Misfolded Protein
Tubulin Deacetylation
Polyamine Deacetylation
Spermidine Deacetylation
Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Signaling Receptor Activity
Pathways
Nuclear Receptor transcription pathway
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HSF1 activation
Notch-HLH transcription pathway
Cilium Assembly
Transcriptional regulation by RUNX2
RUNX2 regulates osteoblast differentiation
Chaperone Mediated Autophagy
Late endosomal microautophagy
Aggrephagy
Aggrephagy
Drugs
Vorinostat
Belinostat
Pracinostat
Romidepsin
Panobinostat
Bufexamac
Diseases
GWAS
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
HDL cholesterol (
24097068
)
LDL cholesterol (
24097068
)
Triglycerides (
24097068
)
Interacting Genes
51 interacting genes:
AR
CHRD
CIDEC
DDX20
EID1
ESR1
ESR2
ESRRA
ESRRG
FN1
GPS2
GPSM3
HDAC3
HDAC6
HNF4A
HNF4G
HNRNPA1
ID2
IL3RA
NCOA3
NEUROD1
NR1H2
NR1H3
NR1I2
NR1I3
NR3C1
NR5A2
PAX9
PEF1
PLSCR1
POLR2A
PPARD
PPARG
RARA
RARG
RBP5
RNF31
RXRA
RXRB
RXRG
SMAD4
SMARCA2
SMARCB1
SMARCE1
SNW1
THRA
TP53
VDR
XBP1
ZAP70
ZMYND10
83 interacting genes:
ADRB2
APOBEC3G
ARHGDIA
ATF3
ATXN3
AURKA
BBS10
BCL3
BCOR
BRMS1
CDKN1A
CEP70
CSNK2A2
CTTN
CYLD
DYNLL2
EGFR
EP300
ERBB2
ERBB3
ERBB4
FBP1
FBXO11
FNTA
FNTB
GRK2
H3C1
H4-16
HDAC11
HES1
HSP90AA1
HTATIP2
HTATSF1
ISG15
JDP2
KPNA1
LCOR
LPXN
MAPK1
MAPK3
MAPT
MLH1
MSH2
NACAD
NASP
NR0B2
NR3C1
PLAA
POLA2
POLDIP2
POLR1B
PPP1CC
PRDX4
PRKCZ
PRKN
PROM1
PTOV1
PXN
RELB
RNF31
RUNX2
SEPTIN7
SIRT2
SYK
TPPP
TRIM50
TUBA1A
TUBA1B
TUBA4A
TUBB
TUBB2A
TUBB2B
UBB
UBC
UBE2D1
UBE2D3
UBE2E1
UBE2H
VCP
VKORC1
YWHAZ
ZBTB16
ZNF205
Entrez ID
8431
10013
HPRD ID
05219
02228
Ensembl ID
ENSG00000131910
ENSG00000094631
Uniprot IDs
Q15466
A0A024QZ26
B4DZH6
Q9BRX7
Q9NSW6
Q9UBN7
PDB IDs
1YUC
2Q3Y
2Z4J
4DOR
4ONI
5UFS
6W9M
3C5K
3GV4
3PHD
5B8D
5EDU
5KH3
5KH7
5KH9
5WBN
5WPB
6CE6
6CE8
6CEA
6CEC
6CED
6CEE
6CEF
Enriched GO Terms of Interacting Partners
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