CASP14 and CASP4

Data Source:
HPRD (in vivo)

		CASP14	CASP4
Description		caspase 14	caspase 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Keratin Filament	Extracellular Region Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Protein-containing Complex IPAF Inflammasome Complex NLRP3 Inflammasome Complex AIM2 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Cysteine-type Endopeptidase Activity Protein Binding CARD Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Proteolysis Epidermis Development Keratinization Cornification Execution Phase Of Apoptosis	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Protein Autoprocessing Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Pyroptosis Intrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Amyloid-beta
Pathways		Formation of the cornified envelope	NOD1/2 Signaling Pathway
Drugs			Incadronic acid
Diseases
GWAS		Metabolite levels ( 23823483)	Major depressive disorder ( 29317602)
Interacting Genes		9 interacting genes: CAPN1 CASP1 CASP10 CASP2 CASP4 CASP8 CDC42 MEOX2 UCHL5	16 interacting genes: APAF1 APP CASP10 CASP14 CASP3 CASP8 DSP ELF4 IL18 IL1B IL37 MYH9 NOD1 PLA2G4A PSEN1 SERPINB9
Entrez ID		23581	837
HPRD ID		05788	04047
Ensembl ID		ENSG00000105141	ENSG00000196954
Uniprot IDs		B2CIS9 P31944	P49662
PDB IDs			6KMZ 6NRY
Enriched GO Terms of Interacting Partners?
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