CASP14 and CASP2

Data Source:
HPRD (in vivo)

		CASP14	CASP2
Description		caspase 14	caspase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Keratin Filament	Nucleus Cytoplasm Mitochondrion Cytosol Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Proteolysis Epidermis Development Keratinization Cornification Execution Phase Of Apoptosis	Luteolysis Neural Retina Development Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Brain Development Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Processing Ectopic Germ Cell Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Execution Phase Of Apoptosis Positive Regulation Of Apoptotic Signaling Pathway
Pathways		Formation of the cornified envelope	NOD1/2 Signaling Pathway NADE modulates death signalling TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CAPN1 CASP1 CASP10 CASP2 CASP4 CASP8 CDC42 MEOX2 UCHL5	31 interacting genes: ADCYAP1 BAG4 BID CASP10 CASP14 CASP3 CASP7 CASP8 CCND3 CFLAR CRADD CSNK2A1 DCTN1 DSP EEF1A1 GOLGA3 GRB2 KPNA2 MDM2 MZB1 NLRP1 NOD1 NOL3 PIDD1 PRKAB2 RAI1 RB1 RPL30 RXRA SUMO1 UBE2I
Entrez ID		23581	835
HPRD ID		05788	02800
Ensembl ID		ENSG00000105141	ENSG00000106144
Uniprot IDs		B2CIS9 P31944	A0A087WYM1 A0A0S2Z3H1 D3DXD9 P42575
PDB IDs			1PYO 2P2C 3R5J 3R6G 3R6L 3R7B 3R7N 3R7S 3RJM 6GKF 6GKG 6S9K 6SAD
Enriched GO Terms of Interacting Partners?
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