HDHD2 and PIP5K1C

Data Source:
HPRD (two hybrid)

		HDHD2	PIP5K1C
Description		haloacid dehalogenase like hydrolase domain containing 2	phosphatidylinositol-4-phosphate 5-kinase type 1 gamma
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GO Annotations	Cellular Component	Extracellular Exosome	Phagocytic Cup Uropod Nucleoplasm Cytosol Adherens Junction Focal Adhesion Endosome Membrane Ruffle Membrane Presynapse
	Molecular Function	Protein Binding Phosphatase Activity Enzyme Binding Metal Ion Binding	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity
	Biological Process	Biological_process Dephosphorylation	Phosphatidylinositol Biosynthetic Process Phagocytosis Regulation Of Phosphatidylinositol 3-kinase Signaling Synaptic Vesicle Exocytosis Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Phosphorylation Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion
Pathways			Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis
Drugs
Diseases			Lethal congenital contractural syndrome (LCCS)
GWAS		Blood protein levels ( 30072576 29875488) Fruit consumption ( 32066663)
Interacting Genes		12 interacting genes: ADGRB2 CFD CRMP1 DVL1 EPHB6 LUC7L2 MEOX2 MGST2 PIP5K1C SOD2 TARBP2 TRAPPC11	17 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 SMURF1 SRC TLN2
Entrez ID		84064	23396
HPRD ID		13640	05834
Ensembl ID		ENSG00000167220	ENSG00000186111
Uniprot IDs		Q9H0R4 V9HW73	O60331
PDB IDs		3HLT	2G35 3H1Z 3H85
Enriched GO Terms of Interacting Partners?
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