PIP5K1C and TLN2

Data Source:
HPRD (in vitro)

		PIP5K1C	TLN2
Description		phosphatidylinositol-4-phosphate 5-kinase type 1 gamma	talin 2
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GO Annotations	Cellular Component	Phagocytic Cup Uropod Nucleoplasm Cytosol Adherens Junction Focal Adhesion Endosome Membrane Ruffle Membrane Presynapse	Ruffle Cytoplasm Plasma Membrane Focal Adhesion Actin Cytoskeleton Synapse
	Molecular Function	Protein Binding ATP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity	Actin Binding Integrin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Actin Filament Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Phagocytosis Regulation Of Phosphatidylinositol 3-kinase Signaling Synaptic Vesicle Exocytosis Actin Cytoskeleton Organization Neutrophil Chemotaxis Adherens Junction Assembly Phosphatidylinositol Phosphorylation Synaptic Vesicle Endocytosis Membrane Organization Clathrin-dependent Endocytosis Cell-cell Adhesion	Cytoskeleton Organization Cell-cell Junction Assembly Cell Adhesion Cell-cell Adhesion
Pathways		Synthesis of PIPs at the plasma membrane SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Clathrin-mediated endocytosis
Drugs
Diseases		Lethal congenital contractural syndrome (LCCS)
GWAS			High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Periventricular white matter hyperintensities ( 32517579) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) White blood cell count ( 32888494)
Interacting Genes		17 interacting genes: AKT1 AKT2 AP1B1 AP2B1 ARF6 BTK CDH1 CDK5 HDHD2 ITGB1 LAPTM4B LRP2 NEDD4 PKD1 SMURF1 SRC TLN2	2 interacting genes: CLK1 PIP5K1C
Entrez ID		23396	83660
HPRD ID		05834	09555
Ensembl ID		ENSG00000186111	ENSG00000171914
Uniprot IDs		O60331	Q9Y4G6
PDB IDs		2G35 3H1Z 3H85	6U4K
Enriched GO Terms of Interacting Partners?
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