TSSK1B and FOXN1

Data Source:
BioGRID (two hybrid)

		TSSK1B	FOXN1
Description		testis specific serine kinase 1B	forkhead box N1
Image		No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Cytoplasm Motile Cilium	Chromatin Nucleus
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	Protein Phosphorylation Multicellular Organism Development Spermatid Development Intracellular Signal Transduction	Hair Follicle Development T Cell Lineage Commitment Regulation Of Transcription By RNA Polymerase II Defense Response Epidermis Development Animal Organ Morphogenesis Keratinocyte Differentiation Positive Regulation Of Epithelial Cell Differentiation Nail Development T Cell Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Positive Regulation Of Hair Follicle Development Lymphoid Lineage Cell Migration Into Thymus Thymus Epithelium Morphogenesis Regulation Of Positive Thymic T Cell Selection
Pathways
Drugs		Fostamatinib
Diseases			T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS			Bone mineral density ( 31790847) Metabolite levels ( 31628463) Tonsillectomy ( 27182965 28928442)
Interacting Genes		8 interacting genes: CHEK2 EFS FAM229B FOXN1 MEOX2 TGFBR1 TGFBR2 TSKS	12 interacting genes: CDA CDC23 DMRT3 HOXA1 LHX8 MAPKBP1 PIN1 SPATC1L TLE5 TRAF2 TRAPPC6A TSSK1B
Entrez ID		83942	8456
HPRD ID		11610	02907
Ensembl ID		ENSG00000212122	ENSG00000109101
Uniprot IDs		A0ZT98 Q9BXA7	O15353
PDB IDs			5OCN 6EL8
Enriched GO Terms of Interacting Partners?
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