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BTK and JAK1
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
BTK
JAK1
Description
Bruton tyrosine kinase
Janus kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Cytoplasmic Vesicle
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleus
Cytoplasm
Endosome
Cytosol
Cytoskeleton
Focal Adhesion
Membrane
Molecular Function
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Identical Protein Binding
Metal Ion Binding
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Growth Hormone Receptor Binding
Protein Binding
ATP Binding
Protein Phosphatase Binding
Ubiquitin Protein Ligase Binding
CCR5 Chemokine Receptor Binding
Metal Ion Binding
Biological Process
Positive Regulation Of Type III Hypersensitivity
Positive Regulation Of Type I Hypersensitivity
Negative Regulation Of Cytokine Production
Adaptive Immune Response
B Cell Affinity Maturation
Histamine Secretion By Mast Cell
Regulation Of B Cell Cytokine Production
MyD88-dependent Toll-like Receptor Signaling Pathway
Regulation Of B Cell Apoptotic Process
Protein Phosphorylation
G Protein-coupled Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Mesoderm Development
Peptidyl-tyrosine Phosphorylation
Calcium-mediated Signaling
Negative Regulation Of B Cell Proliferation
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
B Cell Activation
Innate Immune Response
Positive Regulation Of B Cell Differentiation
Protein Autophosphorylation
Cell Maturation
B Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cellular Response To Molecule Of Fungal Origin
Apoptotic Signaling Pathway
Cellular Response To Interleukin-7
MAPK Cascade
Protein Phosphorylation
Peptidyl-tyrosine Phosphorylation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Homotypic Cell-cell Adhesion
Intracellular Signal Transduction
Interleukin-12-mediated Signaling Pathway
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Response To Antibiotic
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interferon-gamma-mediated Signaling Pathway
Type I Interferon Signaling Pathway
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Protein Localization To Cell-cell Junction
Positive Regulation Of Sprouting Angiogenesis
Pathways
ER-Phagosome pathway
MyD88:MAL(TIRAP) cascade initiated on plasma membrane
Regulation of actin dynamics for phagocytic cup formation
DAP12 signaling
FCERI mediated Ca+2 mobilization
FCERI mediated Ca+2 mobilization
G alpha (q) signalling events
G alpha (12/13) signalling events
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)
RHO GTPases Activate WASPs and WAVEs
G beta:gamma signalling through BTK
FCGR3A-mediated phagocytosis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Interleukin-6 signaling
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
ISG15 antiviral mechanism
Interleukin-7 signaling
Interleukin-7 signaling
Other interleukin signaling
RAF/MAP kinase cascade
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
IL-6-type cytokine receptor ligand interactions
Interferon gamma signaling
Regulation of IFNG signaling
Regulation of IFNG signaling
Interleukin-20 family signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-2 signaling
Interleukin-12 signaling
Interleukin-12 signaling
Interleukin-27 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Interferon alpha/beta signaling
Interleukin receptor SHC signaling
Regulation of IFNA signaling
Regulation of IFNA signaling
Potential therapeutics for SARS
Drugs
Dasatinib
Inositol 1,3,4,5-Tetrakisphosphate
XL418
Ibrutinib
Acalabrutinib
Fostamatinib
Zanubrutinib
Abivertinib
Myricetin
2-tert-butyl-9-fluoro-1,6-dihydrobenzo[h]imidazo[4,5-f]isoquinolin-7-one
Ruxolitinib
Tofacitinib
Baricitinib
Fostamatinib
Fedratinib
Filgotinib
Upadacitinib
Pralsetinib
Diseases
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Autoimmune thyroid disease (
32581359
)
Core binding factor acute myeloid leukemia (
27903959
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of granulocytes (
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Medication use (thyroid preparations) (
31015401
)
Monocyte percentage of white cells (
32888494
)
Multiple sclerosis (
31604244
)
Neutrophil percentage of granulocytes (
27863252
)
Plasma anti-thyroglobulin levels (
29678681
)
Platelet count (
32888494
)
Plateletcrit (
32888494
)
Sum eosinophil basophil counts (
27863252
)
Interacting Genes
76 interacting genes:
ABL1
APP
AR
ARHGAP17
ARID3A
ARRB1
AURKA
BCL2L11
BECN1
BLNK
BMX
CAV1
CBL
CD19
CMTM3
COASY
DAPP1
ERBB3
EWSR1
FAS
FASLG
FYN
GAB1
GNA12
GNAQ
GNG2
GTF2I
HCK
IBTK
IRAK1
ITK
JAK1
KHDRBS1
KIT
LYN
MDM2
MEOX2
MET
MRPS22
MYD88
PIK3AP1
PIK3R3
PIP4K2A
PIP4K2B
PIP4K2C
PIP5K1A
PIP5K1B
PIP5K1C
PLAU
PLCG1
PLCG2
PRKCA
PRKCB
PRKCE
PRKCQ
PRKCZ
PRKD1
RELA
RPS6KB1
RPS6KB2
SH2B2
SH3BP5
SMURF1
STAT5A
SYK
TEC
TIRAP
TLR4
TLR6
TLR8
TLR9
TNFRSF10A
TP53
VAV1
WAS
WASF2
72 interacting genes:
ABL1
AGTR1
BRCA1
BTK
CCR1
CCR5
CSF2RB
CSF3R
CXCR4
EIF2AK2
ELP2
ERBB2
FER
FES
GAB1
GHR
GRB2
H3-4
IFNAR2
IFNGR1
IGF1R
IL10RA
IL21R
IL2RB
IL2RG
IL3RA
IL4R
IL5RA
IL6ST
IL7R
IL9R
INPP5D
INSR
IRS1
IRS2
JAK3
JAKMIP1
MDK
OSMR
PDGFRA
PDGFRB
PIK3R1
PLA2G4A
PLAUR
PLCG2
PRKCZ
PRMT5
PTK2B
PTPN11
PTPN2
PTPN6
PTPRC
RACK1
RAF1
SH2B2
SHB
SOCS1
SOCS3
STAM
STAM2
STAT1
STAT2
STAT3
STAT5A
STAT6
SYK
TEC
TNFRSF1A
TOP1
TSHR
TYK2
USP6
Entrez ID
695
3716
HPRD ID
02248
00992
Ensembl ID
ENSG00000010671
ENSG00000162434
Uniprot IDs
Q06187
Q5JY90
P23458
Q6P669
PDB IDs
1AWW
1AWX
1B55
1BTK
1BWN
1K2P
1QLY
2GE9
2Z0P
3GEN
3K54
3OCS
3OCT
3P08
3PIX
3PIY
3PIZ
3PJ1
3PJ2
3PJ3
4NWM
4OT5
4OT6
4OTF
4OTQ
4OTR
4RFY
4RFZ
4RG0
4RX5
4YHF
4Z3V
4ZLY
4ZLZ
5BPY
5BQ0
5FBN
5FBO
5J87
5JRS
5KUP
5P9F
5P9G
5P9H
5P9I
5P9J
5P9K
5P9L
5P9M
5T18
5U9D
5VFI
5VGO
5XYZ
5ZZ4
6AUA
6AUB
6BIK
6BKE
6BKH
6BKW
6BLN
6DI0
6DI1
6DI3
6DI5
6DI9
6E4F
6EP9
6HRP
6HRT
6HTF
6J6M
6N9P
6NFH
6NFI
6NZM
6O8I
6OMU
6S90
6TFP
6X3N
6X3O
6X3P
6XE4
3EYG
3EYH
4E4L
4E4N
4E5W
4EHZ
4EI4
4FK6
4GS0
4I5C
4IVB
4IVC
4IVD
4K6Z
4K77
4L00
4L01
5E1E
5HX8
5IXD
5IXI
5KHW
5KHX
5L04
5WO4
6AAH
6BBU
6C7Y
6DBN
6ELR
6GGH
6HZU
6N77
6N78
6N79
6N7A
6N7B
6N7C
6N7D
6RSB
6RSC
6RSD
6RSE
6RSH
6SM8
6SMB
6TPE
6TPF
6W8L
Enriched GO Terms of Interacting Partners
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