TMEM120A and PTAFR

Data Source:
BioGRID (two hybrid)

		TMEM120A	PTAFR
Description		transmembrane protein 120A	platelet activating factor receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nuclear Inner Membrane Plasma Membrane Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Secretory Granule Membrane Tertiary Granule Membrane
	Molecular Function	Molecular_function Ion Channel Activity Protein Binding	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity G Protein-coupled Receptor Activity Platelet Activating Factor Receptor Activity Protein Binding Phospholipid Binding G Protein-coupled Purinergic Nucleotide Receptor Activity Mitogen-activated Protein Kinase Binding
	Biological Process	Ion Transmembrane Transport Fat Cell Differentiation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Protein Homooligomerization Protein Heterooligomerization	Positive Regulation Of Cellular Extravasation Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Parturition Response To Symbiotic Bacterium Positive Regulation Of Phospholipase C Activity Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Transcytosis Positive Regulation Of Translation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Inositol Phosphate Biosynthetic Process Cellular Response To Gravity Cellular Response To CAMP Cellular Response To Fatty Acid Response To Dexamethasone Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Transcytosis Positive Regulation Of Maternal Process Involved In Parturition Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Cellular Response To 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
Pathways			Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events Interleukin-10 signaling Neutrophil degranulation Interferon gamma signaling
Drugs			Platelet Activating Factor Etizolam Rupatadine
Diseases
GWAS		Coffee consumption ( 25288136) Coffee consumption (cups per day) ( 25288136)	Blond vs. brown/black hair color ( 30531825)
Interacting Genes		24 interacting genes: AQP6 CYBRD1 FAM209A FBXO7 GOT1 GPRC5B HSD17B13 LEPROT LRRC25 ORMDL2 PAXIP1 PPP1CC PTAFR SCN3B STX1A STX2 TMEM14B TMEM35A TMEM86B TMX2 TPRG1 TSPAN18 UBC VKORC1	19 interacting genes: ARR3 ARRB2 CALM1 GORAB GRIN1 GTPBP3 IFITM3 MBP MFSD3 PLLP PPM1J PRNP RGS4 RHBDD2 SERINC5 SPATA24 TMEM120A TMX2 TYK2
Entrez ID		83862	5724
HPRD ID		15543	01422
Ensembl ID		ENSG00000189077	ENSG00000169403
Uniprot IDs		A0A087X266 Q9BXJ8	A8K7N8 P25105
PDB IDs			2B0X
Enriched GO Terms of Interacting Partners?
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