GUCD1 and ADAM12

Data Source:
BioGRID (two hybrid)

		GUCD1	ADAM12
Description		guanylyl cyclase domain containing 1	ADAM metallopeptidase domain 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding
	Biological Process		Proteolysis Cell Adhesion Myoblast Fusion Extracellular Matrix Organization Positive Regulation Of Angiogenesis
Pathways			Signaling by EGFR Invadopodia formation
Drugs
Diseases
GWAS		Acne (severe) ( 24927181)	Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Interacting Genes		77 interacting genes: ADAM12 ADAMTSL4 APP ATP23 BEGAIN CCDC153 CPSF7 CRX CTAG1A CTAG1B CTH CYSRT1 FCHO1 FHL3 FUCA2 HESX1 HOXA1 HSPB7 ID3 ISCA2 KATNBL1 KPRP KRT40 KRTAP1-1 KRTAP1-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP13-3 KRTAP19-5 KRTAP19-6 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-6 KRTAP5-7 KRTAP9-2 KRTAP9-8 LASP1 LCE1C LCE2A LCE2B LCE2D LHX3 LNX1 MAP2K5 MEOX2 MORN3 MORN4 NDUFAF6 NGLY1 PCBD2 PCSK5 PFDN5 PSMA1 PTH1R RSPO4 RUNX3 SLC25A48 SMCP SPRY1 SYNGAP1 TCF4 TEPSIN TFAP2D TOLLIP TRIM42 TSPAN4 TXN2 VASN YPEL3 ZBTB42 ZCCHC13 ZNF250 ZNF655 ZNF705D ZNF835	40 interacting genes: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1
Entrez ID		83606	8038
HPRD ID		12796	04092
Ensembl ID		ENSG00000138867	ENSG00000148848
Uniprot IDs		A0A024R1B8 A0A087WVD9 B4DL90 E7EX77 E9PGZ7 Q7Z629 Q96NT3	A8K6G4 O43184 U5NE98
PDB IDs
Enriched GO Terms of Interacting Partners?
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