ADAM12 and KRT83

Data Source:
BioGRID (two hybrid)

		ADAM12	KRT83
Description		ADAM metallopeptidase domain 12	keratin 83
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Plasma Membrane Integral Component Of Membrane	Extracellular Space Cytosol Keratin Filament
	Molecular Function	Metalloendopeptidase Activity Protein Binding Metallopeptidase Activity SH3 Domain Binding Metal Ion Binding	Protein Binding
	Biological Process	Proteolysis Cell Adhesion Myoblast Fusion Extracellular Matrix Organization Positive Regulation Of Angiogenesis	Aging Epidermis Development Keratinization Hair Cycle Cornification
Pathways		Signaling by EGFR Invadopodia formation	Keratinization Formation of the cornified envelope
Drugs
Diseases			Monilethrix
GWAS		Blood protein levels ( 30072576) Endometrial cancer ( 24096698) Extremely high intelligence ( 29731509) Heel bone mineral density ( 30598549) Intraocular pressure ( 30054594) Itch intensity from mosquito bite ( 28199695) Loneliness ( 27629369) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Mild influenza (H1N1) infection ( 26379185) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070 27021288) Placental abruption ( 29884306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Visceral fat ( 22589738)
Interacting Genes		40 interacting genes: ACTN2 ADAMTSL4 CYSRT1 EGF ESM1 FHL5 FSTL3 GRB2 GUCD1 HOXA1 IGFBP3 IGFBP5 KRT83 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP12-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-6 KRTAP5-9 KRTAP6-2 KRTAP9-2 KRTAP9-8 LCE5A MAPKBP1 NBPF19 NOTCH2NLA OTX1 PACSIN3 PIK3R1 RECK SH3D19 SLC15A2 SPRY1 SPRY4 SRC TFAP2D YES1	40 interacting genes: ADAM12 ANKS1A C11orf87 CEP57 CREB5 CYSRT1 GEM GNE GSTP1 HOXA1 KRT15 KRT16 KRT19 KRT25 KRT27 KRT31 KRT33B KRT34 KRT35 KRT37 KRT38 KRT39 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP13-3 KRTAP3-3 KRTAP6-2 MEOX2 NBPF19 NOTCH2NLA NRF1 OIP5 PITX1 PLEKHN1 POU4F2 ZDHHC1
Entrez ID		8038	3889
HPRD ID		04092	09097
Ensembl ID		ENSG00000148848	ENSG00000170523
Uniprot IDs		A8K6G4 O43184 U5NE98	P78385
PDB IDs
Enriched GO Terms of Interacting Partners?
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