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USP8 and TRIM55
Data Source:
BioGRID
(enzymatic study)
USP8
TRIM55
Description
ubiquitin specific peptidase 8
tripartite motif containing 55
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Early Endosome
Cytosol
Postsynaptic Density
Extrinsic Component Of Plasma Membrane
Midbody
Extrinsic Component Of Endosome Membrane
Dendritic Spine
Glutamatergic Synapse
Nucleus
Cytoplasm
Microtubule
Molecular Function
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
SH3 Domain Binding
Cadherin Binding
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Biological Process
Mitotic Cytokinesis
Ubiquitin-dependent Protein Catabolic Process
Endosome Organization
Ras Protein Signal Transduction
Protein Deubiquitination
Protein Phosphopantetheinylation
Regulation Of Protein Stability
Regulation Of Protein Localization
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Cellular Response To Dexamethasone Stimulus
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Cellular Response To Nerve Growth Factor Stimulus
Leukocyte Migration Involved In Inflammatory Response
Signal Transduction
Protein Ubiquitination
Diapedesis
Macrophage Migration
Pathways
Downregulation of ERBB2:ERBB3 signaling
Regulation of FZD by ubiquitination
Ub-specific processing proteases
Negative regulation of MET activity
Drugs
Diseases
GWAS
Ankylosing spondylitis (
30946743
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Heel bone mineral density (
30598549
)
Mean reticulocyte volume (
32888494
)
Monocyte percentage of white cells (
32888494
)
Coronary heart disease event reduction (statin therapy interaction) (
22666496
)
Metabolite levels (
23823483
)
Recurrent major depressive disorder (
29317602
)
Interacting Genes
40 interacting genes:
BACE1
BIRC6
CFLAR
CHMP1A
CHMP1B
CHMP2A
CHMP2B
CHMP4C
CHMP7
DNAJB6
EPS15
GRAP2
GRB2
H2AC20
H2BC21
KIF23
NBR1
PJA1
PLA2G2A
RASGRF1
RNF41
SEC31A
SHANK1
SHANK3
SLBP
SNCA
SPP1
SRC
STAM
STAM2
TRIM54
TRIM55
TRIM63
UBC
USP15
USP21
USP28
YWHAG
YWHAQ
YWHAZ
310 interacting genes:
ACBD4
ACD
ACTA1
ADAMTSL4
AEBP2
AFM
AGO2
AKR1C8P
ALKBH3
ANKRD1
ANKRD39
APLN
APOBEC4
ARL6IP4
ATG4D
ATP5F1B
ATP5F1D
ATXN3
ATXN3L
ATXN7L1
BCAT1
BCHE
BRAP
BRD4
BRWD1
BTBD9
BYSL
C10orf88
C12orf4
C1orf35
C3orf36
C8orf74
CADPS
CAMK2A
CAPN3
CARS1
CBX2
CCDC120
CCDC130
CCDC28B
CDK3
CDS2
CENPK
CHMP7
CKM
COA7
COX4I1
CRCT1
CTAG1A
CTAG1B
CTNNB1
CTSF
CYB5R2
CYP46A1
CYTOR
DAPL1
DCAF11
DCAF6
DCTN3
DECR2
DEF8
DEK
DES
DNTTIP1
DOCK7
DYNLT2B
EED
EEF1G
EHHADH
EIF3E
ELAPOR1
EPS8L2
ESPL1
EZH2
FAM185A
FAM90A1
FANK1
FASTKD1
FHL2
FKBP6
FLNA
FLNB
FLNC
FRMD6
FYN
GABPB1
GATA3
GFM1
GLI4
GMEB1
GOLGA2P5
GPRIN2
GPS1
GRB10
GRB14
HID1
HIRA
HOXA1
HROB
HSPB1
ID1
IFI35
IGF2
IK
IL37
ILF3
INCA1
ING4
INKA1
IQUB
IRF2
IRF3
ITGB5
JADE3
KBTBD4
KCTD15
KIAA0087
KIAA0408
KIF13A
KIF1B
KIF5A
KLHDC4
KLHL36
KMT2B
KYAT1
LAGE3
LAMTOR5
LAPTM4A
LIMS2
LINC00518
LINC00663
LINC00905
LINC01588
LMCD1
LMO2
LRRC56
LYN
LYNX1
MAGEC3
MALSU1
MAP3K14
MBD4
MBIP
MCM7
MDM4
MIDN
MIIP
MKI67
MLH3
MLLT11
MPP1
MPZL1
MRPL19
MRPL20-AS1
MRPL41
MSRB3
MYBPC1
MYBPC3
MYBPHL
MYC
MYCT1
MYOT
MYOZ1
NDUFA1
NDUFA8
NEB
NEBL
NEFL
NGEF
NOMO1
NR1D2
NR2C2
NSD3
NSUN7
NUFIP2
ODF2
OGFOD2
OTUB1
OTUB2
P3H3
PACRGL
PAFAH1B2
PCGF1
PCGF3
PCGF6
PELI3
PELO
PHC2
PHF23
PIAS1
PIAS2
PIAS3
PIP4K2B
PKM
PLEKHG4
PLXNA3
POLD1
POLR2E
PPARA
PPIE
PRKAB2
PRKACA
PRR30
PRRT1
PYGM
RABEPK
RAD23A
RAI2
RBM14
RELA
REX1BD
RGR
RHEB
RHPN1
RING1
RNF10
RNF114
RPS4X
RRAS
RUSC1
RUSC1-AS1
SEC23B
SET
SHFL
SLC6A13
SLFN12
SNW1
SPATS1
SPRYD7
SPSB1
SPSB2
SQSTM1
STAM
SYMPK
SYNCRIP
TCAP
TCP10L
TEX19
THAP3
TIGD5
TIMM17B
TMBIM1
TMEM35A
TNIP3
TNNI1
TNNI2
TNNI3
TOR1AIP2
TPD52L3
TRAF3IP2
TRIB3
TRIM23
TRIM27
TRIM35
TRIM41
TRIM54
TRIM63
TRIM69
TRMT10B
TSC2
TSC22D4
TTN
TUBGCP4
UBA3
UBE2D1
UBE2D2
UBE2D3
UBE2E3
UBE2L3
UCHL3
UCHL5
UNKL
USP13
USP28
USP4
USP5
USP7
USP8
UXT
VAC14
VPS37A
WT1
XAGE1B
YOD1
YPEL3
ZBTB14
ZBTB17
ZC2HC1C
ZC3H12A
ZC3HC1
ZFYVE19
ZNF124
ZNF20
ZNF302
ZNF333
ZNF345
ZNF431
ZNF436
ZNF460
ZNF566
ZNF57
ZNF581
ZNF597
ZNF649
ZNF653
ZNF667-AS1
ZNF767P
ZNF775
ZNF83
ZSCAN16
Entrez ID
9101
84675
HPRD ID
04405
05927
Ensembl ID
ENSG00000138592
ENSG00000147573
Uniprot IDs
A0A024R5S4
A8K8N5
P40818
Q9BYV6
PDB IDs
1WHB
2A9U
2GFO
2GWF
3N3K
6F09
Enriched GO Terms of Interacting Partners
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