H2AC13 and RNF168

Data Source:
BioGRID (enzymatic study)

		H2AC13	RNF168
Description		H2A clustered histone 13	ring finger protein 168
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GO Annotations	Cellular Component	Nucleosome Nucleus Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break
	Molecular Function	DNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Chromatin Silencing Biological_process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination
Pathways		HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases			RIDDLE syndrome
GWAS			Fat distribution (HIV) ( 21897333) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		2 interacting genes: RNF168 SUPT16H	32 interacting genes: ALAS1 ECPAS H2AC13 H2AC18 H2AC20 H2AC4 H2AX H2AZ1 H2BC21 JMJD1C KDM1A KDM4A LAPTM5 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2L3 USP7 WBP2
Entrez ID		8329	165918
HPRD ID		04153	08190
Ensembl ID		ENSG00000196747	ENSG00000163961
Uniprot IDs		A4FTV9 P0C0S8	Q8IYW5
PDB IDs		4QYL 5KGF 6R0C 6RNY 6X59 6X5A 6XJD 7JO9 7JOA	3L11 4GB0 5XIS 5XIT 5XIU 5YDK
Enriched GO Terms of Interacting Partners?
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