RNF168 and H2AC13

Data Source:
BioGRID (enzymatic study)

		RNF168	H2AC13
Description		ring finger protein 168	H2A clustered histone 13
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol Protein-containing Complex Site Of Double-strand Break	Nucleosome Nucleus Extracellular Exosome
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Nucleosome Binding Histone Binding Ubiquitin Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	DNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Response To Ionizing Radiation Protein Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2A Monoubiquitination Interstrand Cross-link Repair Histone H2A-K13 Ubiquitination Histone H2A-K15 Ubiquitination Isotype Switching Positive Regulation Of DNA Repair Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination	Chromatin Silencing Biological_process
Pathways		SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint	HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines UCH proteinases Ub-specific processing proteases Metalloprotease DUBs HCMV Early Events HCMV Late Events
Drugs
Diseases		RIDDLE syndrome
GWAS		Fat distribution (HIV) ( 21897333) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		32 interacting genes: ALAS1 ECPAS H2AC13 H2AC18 H2AC20 H2AC4 H2AX H2AZ1 H2BC21 JMJD1C KDM1A KDM4A LAPTM5 PALB2 PARP1 RABGEF1 RNF11 RNF126 SQSTM1 SUMO2 TNFAIP3 TOP2A TRIM8 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G2 UBE2L3 USP7 WBP2	2 interacting genes: RNF168 SUPT16H
Entrez ID		165918	8329
HPRD ID		08190	04153
Ensembl ID		ENSG00000163961	ENSG00000196747
Uniprot IDs		Q8IYW5	A4FTV9 P0C0S8
PDB IDs		3L11 4GB0 5XIS 5XIT 5XIU 5YDK	4QYL 5KGF 6R0C 6RNY 6X59 6X5A 6XJD 7JO9 7JOA
Enriched GO Terms of Interacting Partners?
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