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RNF168 and H2AZ1
Data Source:
BioGRID
(pull down)
RNF168
H2AZ1
Description
ring finger protein 168
H2A.Z variant histone 1
Image
GO Annotations
Cellular Component
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Protein-containing Complex
Site Of Double-strand Break
Nucleosome
Euchromatin
Heterochromatin
Barr Body
Nucleus
Extracellular Exosome
Molecular Function
Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Nucleosome Binding
Histone Binding
Ubiquitin Binding
Metal Ion Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
DNA Binding
Protein Binding
Chromatin DNA Binding
Nucleosomal DNA Binding
Protein Heterodimerization Activity
Biological Process
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Ubiquitin-dependent Protein Catabolic Process
Cellular Response To DNA Damage Stimulus
Response To Ionizing Radiation
Protein Ubiquitination
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Histone H2A Monoubiquitination
Interstrand Cross-link Repair
Histone H2A-K13 Ubiquitination
Histone H2A-K15 Ubiquitination
Isotype Switching
Positive Regulation Of DNA Repair
Protein K63-linked Ubiquitination
Histone H2A K63-linked Ubiquitination
Chromatin Silencing
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Estradiol Stimulus
Pathways
SUMOylation of DNA damage response and repair proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Nonhomologous End-Joining (NHEJ)
Processing of DNA double-strand break ends
G2/M DNA damage checkpoint
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
Drugs
Diseases
RIDDLE syndrome
GWAS
Fat distribution (HIV) (
21897333
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Triglyceride levels (
32203549
)
Interacting Genes
32 interacting genes:
ALAS1
ECPAS
H2AC13
H2AC18
H2AC20
H2AC4
H2AX
H2AZ1
H2BC21
JMJD1C
KDM1A
KDM4A
LAPTM5
PALB2
PARP1
RABGEF1
RNF11
RNF126
SQSTM1
SUMO2
TNFAIP3
TOP2A
TRIM8
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G2
UBE2L3
USP7
WBP2
7 interacting genes:
FH
INCENP
MAGEC1
NCAPH
RNF168
RNF169
USP16
Entrez ID
165918
3015
HPRD ID
08190
00823
Ensembl ID
ENSG00000163961
ENSG00000164032
Uniprot IDs
Q8IYW5
P0C0S5
PDB IDs
3L11
4GB0
5XIS
5XIT
5XIU
5YDK
1F66
3WA9
4CAY
4NFT
5B31
5B32
5B33
5CHL
5FUG
5Z30
6JOU
6KO2
Enriched GO Terms of Interacting Partners
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