PICALM and PLCG1

Data Source:
HPRD (in vitro)

		PICALM	PLCG1
Description		phosphatidylinositol binding clathrin assembly protein	phospholipase C gamma 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Synaptic Vesicle Cell Surface Membrane AP-2 Adaptor Complex Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Intrinsic Component Of Membrane Vesicle Presynaptic Membrane Neuronal Cell Body Intracellular Membrane-bounded Organelle Postsynaptic Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Endosome To Plasma Membrane Transport Vesicle Neurofibrillary Tangle Extrinsic Component Of Presynaptic Endocytic Zone Membrane	Ruffle Cytoplasm Cytosol Plasma Membrane Cell-cell Junction COP9 Signalosome Lamellipodium Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	SNARE Binding Amyloid-beta Binding Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Clathrin Binding Small GTPase Binding Clathrin Heavy Chain Binding Cadherin Binding Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding	Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Neurotrophin TRKA Receptor Binding Calcium Ion Binding Protein Binding Protein Kinase Binding Receptor Tyrosine Kinase Binding Glutamate Receptor Binding Calcium-dependent Phospholipase C Activity
	Biological Process	Endocytosis Receptor-mediated Endocytosis Vesicle Budding From Membrane Axonogenesis Learning Or Memory Negative Regulation Of Gene Expression Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Synaptic Vesicle Maturation Vesicle-mediated Transport Endosomal Transport Hemopoiesis Regulation Of Endocytosis Receptor Internalization Regulation Of Protein Localization Vesicle Cargo Loading Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Receptor-mediated Endocytosis Clathrin Coat Assembly Dendrite Morphogenesis Iron Ion Homeostasis Membrane Organization Protein-containing Complex Assembly Clathrin-dependent Endocytosis Modulation Of Age-related Behavioral Decline Regulation Of Vesicle Size Membrane Bending Amyloid-beta Clearance By Transcytosis Positive Regulation Of Neuron Death Regulation Of Amyloid-beta Formation Positive Regulation Of Amyloid-beta Formation Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Positive Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Metalloendopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Protein Localization To Plasma Membrane Clathrin-coated Pit Assembly Negative Regulation Of Protein Localization To Cell Surface	In Utero Embryonic Development Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Axon Guidance Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Phospholipase C Activity Viral Process Cell Migration Calcium-mediated Signaling Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Blood Vessel Endothelial Cell Migration Inositol Phosphate Metabolic Process Positive Regulation Of Angiogenesis Phosphatidylinositol Metabolic Process Modulation Of Chemical Synaptic Transmission T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Epidermal Growth Factor Stimulus Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 point mutants in cancer RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS		Alzheimer's disease ( 22832961 19734902 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 30617256 24162737) Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Chronic obstructive pulmonary disease ( 30804561) Family history of Alzheimer's disease ( 30617256) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) IgG response to Plasmodium falciparum antigens (GLURP, MSP2 FC27, MSP2 3D7) ( 26741287) Mean platelet volume ( 32888494) Platelet count ( 32888494 27863252) Refractive error ( 32231278) Tourette syndrome ( 22889924)	Apolipoprotein B levels ( 32203549) Birth weight ( 31043758) Brain morphology (MOSTest) ( 32665545) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) Major depressive disorder ( 27479909) Male-pattern baldness ( 28196072) Refractive error ( 32231278) Triglyceride levels ( 32203549)
Interacting Genes		19 interacting genes: AP2A1 ATXN1 ATXN1L CASP3 CASP8 CDC42 CLTC CLTCL1 CRX DDIT3 EHD2 FCHO1 ITSN1 PELI2 PLCG1 RBPMS SMURF1 TENM1 ZC3H10	111 interacting genes: ABL1 AGAP2 AGTR1 AKT1 ALK AR ARHGAP32 ARHGEF5 AXL BAG3 BCR BLNK BTK CBL CD22 CD28 CTSS DAB1 DAPP1 DDR1 DGKZ DNM1 DOK1 EEF1A1 EGFR EPHB2 EPOR ERBB2 ERBB3 ERBB4 FGFR1 FGFR2 FGFR4 FLT1 FYN GAB1 GAB2 GHR GIT1 GRAP GRB2 GRIN1 GRIN2A GRIN2B GSN GTF2H1 HCK INPP5D INSR IRS2 ITK KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LIFR LYN MAPT MET MST1R NCAM1 NCK1 NPM1 NTRK1 NTRK2 NTRK3 PAK1 PDGFRA PDGFRB PECAM1 PICALM PITPNA PKN2 PLD2 PRKD1 PRMT8 PTK2 PTPN11 PTPRJ RACK1 RET RHOA RHOU SELE SH2D2A SH3BP2 SHB SHC1 SNAP91 SOCS7 SOS1 SOS2 SRC SYK SYN1 SYNCRIP TEC TNK1 TRIM14 TRPC3 TRPM7 TUB USO1 VAV1 VAV3 VIL1 WAS ZAP70
Entrez ID		8301	5335
HPRD ID		04320	01398
Ensembl ID		ENSG00000073921	ENSG00000124181
Uniprot IDs		A0A024R5L7 A0A024R5P1 Q13492	P19174 Q4LE43 Q9UFY1
PDB IDs			1HSQ 2HSP 4EY0 4FBN
Enriched GO Terms of Interacting Partners?
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