MKKS and PRSS2

Data Source:
BioGRID (affinity chromatography technology)

		MKKS	PRSS2
Description		McKusick-Kaufman syndrome	serine protease 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Centrosome Cytosol Motile Cilium Kinociliary Basal Body	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen
	Molecular Function	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding ATP Binding Unfolded Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Heart Looping Protein Folding Spermatid Development Determination Of Left/right Symmetry Heart Development Visual Perception Sensory Perception Of Smell Gonad Development Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Actin Filament Polymerization Melanosome Transport Developmental Process Negative Regulation Of GTPase Activity Social Behavior Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Vasodilation Fat Cell Differentiation Photoreceptor Cell Maintenance Negative Regulation Of Blood Pressure Intracellular Transport Brain Morphogenesis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Chaperone-mediated Protein Complex Assembly Cartilage Development Regulation Of Stress Fiber Assembly Pigment Granule Aggregation In Cell Center Convergent Extension Involved In Gastrulation Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Non-motile Cilium Assembly	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Neutrophil Degranulation Positive Regulation Of Cell Adhesion
Pathways		BBSome-mediated cargo-targeting to cilium	Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides
Drugs			Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine
Diseases		46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome Bardet-Biedl syndrome (BBS)	Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS			Blood protein levels ( 29875488) Pancreatitis ( 23143602)
Interacting Genes		4 interacting genes: APP CDR2 PTN ZBED1	7 interacting genes: APP BPI CSN1S1 GLP1R MMP9 SERPINA1 SLPI
Entrez ID		8195	5645
HPRD ID		05356	03335
Ensembl ID		ENSG00000125863	ENSG00000275896
Uniprot IDs		B7Z3W9 Q9NPJ1	A6XMV9 P07478 Q5NV56 Q6PK75
PDB IDs
Enriched GO Terms of Interacting Partners?
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