PRSS2 and BPI

Data Source:
HPRD (in vitro)

		PRSS2	BPI
Description		serine protease 2	bactericidal permeability increasing protein
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Matrix Azurophil Granule Lumen	Extracellular Region Extracellular Space Membrane Azurophil Granule Lumen Specific Granule Lumen Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Lipopolysaccharide Binding
	Biological Process	Proteolysis Digestion Antimicrobial Humoral Response Extracellular Matrix Disassembly Positive Regulation Of Cell Growth Collagen Catabolic Process Neutrophil Degranulation Positive Regulation Of Cell Adhesion	Antimicrobial Humoral Response Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Macrophage Activation Neutrophil Degranulation Innate Immune Response Defense Response To Gram-negative Bacterium
Pathways		Collagen degradation Alpha-defensins Activation of Matrix Metalloproteinases Neutrophil degranulation Antimicrobial peptides	Toll Like Receptor 4 (TLR4) Cascade Neutrophil degranulation Antimicrobial peptides
Drugs		Monoisopropylphosphorylserine O-Benzylsulfonyl-Serine Benzylamine Benzamidine Phosphorylisopropane Phenethylamine 3-Phenylpropylamine	Di-Stearoyl-3-Sn-Phosphatidylcholine
Diseases		Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS		Blood protein levels ( 29875488) Pancreatitis ( 23143602)	Basophil count ( 32888494) Blood protein levels ( 29875488) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Monocyte percentage of white cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: APP BPI CSN1S1 GLP1R MMP9 SERPINA1 SLPI	1 interacting genes: PRSS2
Entrez ID		5645	671
HPRD ID		03335	00174
Ensembl ID		ENSG00000275896	ENSG00000101425
Uniprot IDs		A6XMV9 P07478 Q5NV56 Q6PK75	P17213
PDB IDs			1BP1 1EWF
Enriched GO Terms of Interacting Partners?
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