SEH1L and ATP6V0A1

Data Source:
BioGRID (two hybrid)

		SEH1L	ATP6V0A1
Description		SEH1 like nucleoporin	ATPase H+ transporting V0 subunit a1
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Lysosomal Membrane Cytosol Nuclear Pore Outer Ring Seh1-associated Complex Host Cell GATOR2 Complex	Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Integral Component Of Membrane Vacuolar Proton-transporting V-type ATPase Complex Nuclear Speck Secretory Granule Membrane Phagocytic Vesicle Membrane Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding
	Biological Process	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Nuclear Pore Organization Mitotic Metaphase Plate Congression Viral Process Protein Sumoylation Viral Transcription Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Protein-containing Complex Localization Defense Response To Gram-positive Bacterium Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat Positive Regulation Of TORC1 Signaling	Vacuolar Acidification Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Neutrophil Degranulation Phagosome Acidification Toxin Transport Proton Transmembrane Transport
Pathways		Amino acids regulate mTORC1	ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport
Drugs			Tiludronic acid
Diseases
GWAS		Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Lateral ventricle volume ( 31530798) Lead levels in blood ( 25820613) Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan) ( 28521775)	Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		1 interacting genes: ATP6V0A1	7 interacting genes: ABLIM2 CLIC1 CYTH2 HRH1 SEH1L SNX4 ZNF267
Entrez ID		81929	535
HPRD ID		15319	01886
Ensembl ID		ENSG00000085415	ENSG00000033627
Uniprot IDs		Q96EE3	Q53ET5 Q53X12 Q5CZH6 Q93050
PDB IDs		5A9Q
Enriched GO Terms of Interacting Partners?
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