ATP6V0A1 and SEH1L

Data Source:
BioGRID (two hybrid)

		ATP6V0A1	SEH1L
Description		ATPase H+ transporting V0 subunit a1	SEH1 like nucleoporin
Image		No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Lysosomal Membrane Golgi Apparatus Cytosol Plasma Membrane Endosome Membrane Integral Component Of Membrane Vacuolar Proton-transporting V-type ATPase Complex Nuclear Speck Secretory Granule Membrane Phagocytic Vesicle Membrane Melanosome Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Membrane	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Lysosomal Membrane Cytosol Nuclear Pore Outer Ring Seh1-associated Complex Host Cell GATOR2 Complex
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Structural Molecule Activity Protein Binding
	Biological Process	Vacuolar Acidification Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Neutrophil Degranulation Phagosome Acidification Toxin Transport Proton Transmembrane Transport	Regulation Of Glycolytic Process MRNA Export From Nucleus TRNA Export From Nucleus Nuclear Pore Organization Mitotic Metaphase Plate Congression Viral Process Protein Sumoylation Viral Transcription Positive Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Cellular Protein-containing Complex Localization Defense Response To Gram-positive Bacterium Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Gene Silencing By MiRNA Intracellular Transport Of Virus Regulation Of Cellular Response To Heat Positive Regulation Of TORC1 Signaling
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Ion channel transport	Amino acids regulate mTORC1
Drugs		Tiludronic acid
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)	Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435) Lateral ventricle volume ( 31530798) Lead levels in blood ( 25820613) Subclinical trait of interstitial lung disease (basilar peel-core ratio of high attentuation areas on CT scan) ( 28521775)
Interacting Genes		7 interacting genes: ABLIM2 CLIC1 CYTH2 HRH1 SEH1L SNX4 ZNF267	1 interacting genes: ATP6V0A1
Entrez ID		535	81929
HPRD ID		01886	15319
Ensembl ID		ENSG00000033627	ENSG00000085415
Uniprot IDs		Q53ET5 Q53X12 Q5CZH6 Q93050	Q96EE3
PDB IDs			5A9Q
Enriched GO Terms of Interacting Partners?
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