QTRT1 and COPS6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		QTRT1	COPS6
Description		queuine tRNA-ribosyltransferase catalytic subunit 1	COP9 signalosome subunit 6
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GO Annotations	Cellular Component	Nucleus Mitochondrial Outer Membrane Protein-containing Complex	Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm
	Molecular Function	Queuine TRNA-ribosyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Metallopeptidase Activity Isopeptidase Activity
	Biological Process	TRNA Modification TRNA-guanine Transglycosylation	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Viral Process Post-translational Protein Modification
Pathways		tRNA modification in the nucleus and cytosol	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) FEV1 ( 30804560) Inflammatory skin disease ( 25574825) Lung function (FVC) ( 30804560) Psoriasis ( 25903422)	Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: COPS6 NDUFA4L2 RHOU SETDB1 SH3GL3 UNC119 ZBTB16	93 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS7B COPS8 COPS9 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHC3 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24
Entrez ID		81890	10980
HPRD ID		17943	16735
Ensembl ID		ENSG00000213339	ENSG00000168090
Uniprot IDs		Q71RF8 Q9BXR0	Q7L5N1
PDB IDs		6H42 6H45	4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I
Enriched GO Terms of Interacting Partners?
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