QTRT1 and SH3GL3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		QTRT1	SH3GL3
Description		queuine tRNA-ribosyltransferase catalytic subunit 1	SH3 domain containing GRB2 like 3, endophilin A3
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GO Annotations	Cellular Component	Nucleus Mitochondrial Outer Membrane Protein-containing Complex	Acrosomal Vesicle Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Queuine TRNA-ribosyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity	Protein Binding Protein C-terminus Binding Lipid Binding Identical Protein Binding
	Biological Process	TRNA Modification TRNA-guanine Transglycosylation	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis
Pathways		tRNA modification in the nucleus and cytosol	EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) FEV1 ( 30804560) Inflammatory skin disease ( 25574825) Lung function (FVC) ( 30804560) Psoriasis ( 25903422)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 28552196 25282103 18391950 18391951 20397748) Hip circumference adjusted for BMI ( 28552196) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Spine bone size ( 31053729) Working memory ( 31598132)
Interacting Genes		7 interacting genes: COPS6 NDUFA4L2 RHOU SETDB1 SH3GL3 UNC119 ZBTB16	51 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33
Entrez ID		81890	6457
HPRD ID		17943	04528
Ensembl ID		ENSG00000213339	ENSG00000140600
Uniprot IDs		Q71RF8 Q9BXR0	A0A024R215 Q99963
PDB IDs		6H42 6H45	2EW3 2Z0V
Enriched GO Terms of Interacting Partners?
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