SLC7A5 and SLC3A2

Data Source:
HPRD (in vitro)

		SLC7A5	SLC3A2
Description		solute carrier family 7 member 5	solute carrier family 3 member 2
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GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Basal Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Microvillus Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome External Side Of Apical Plasma Membrane Amino Acid Transport Complex	Nucleoplasm Lysosomal Membrane Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cell Junction Melanosome Extracellular Exosome Amino Acid Transport Complex
	Molecular Function	Protein Binding Amino Acid Transmembrane Transporter Activity Aromatic Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity L-tryptophan Transmembrane Transporter Activity Thyroid Hormone Transmembrane Transporter Activity Peptide Antigen Binding	RNA Binding Double-stranded RNA Binding Catalytic Activity Calcium:sodium Antiporter Activity Protein Binding Aromatic Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Cadherin Binding
	Biological Process	Positive Regulation Of Cytokine Production Involved In Immune Response Amino Acid Transmembrane Transport Negative Regulation Of Gene Expression Neutral Amino Acid Transport Phenylalanine Transport Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-4 Production Xenobiotic Transport Leukocyte Migration Thyroid Hormone Transport Amino Acid Import Across Plasma Membrane Leucine Import Across Plasma Membrane Transport Across Blood-brain Barrier L-alpha-amino Acid Transmembrane Transport L-leucine Import Across Plasma Membrane L-tryptophan Transmembrane Transport	Carbohydrate Metabolic Process Calcium Ion Transport Amino Acid Transport Phenylalanine Transport Tryptophan Transport Sodium Ion Transmembrane Transport Response To Exogenous DsRNA Leukocyte Migration Leucine Import Across Plasma Membrane L-alpha-amino Acid Transmembrane Transport L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane
Pathways		Basigin interactions Amino acid transport across the plasma membrane Tryptophan catabolism	Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI) Tryptophan catabolism
Drugs
Diseases
GWAS		Blood metabolite levels ( 24816252) Hematocrit ( 32888494) Hemoglobin ( 32888494) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494)	Iron status biomarkers (transferrin saturation) ( 28334935)
Interacting Genes		1 interacting genes: SLC3A2	16 interacting genes: CCR4 EBP EGFR GPR37 HNRNPD ICAM1 ITGB1 MTNR1B NPSR1 SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 TLCD3A VHL
Entrez ID		8140	6520
HPRD ID		02552	01148
Ensembl ID		ENSG00000103257	ENSG00000168003
Uniprot IDs		Q01650	J3KPF3 P08195
PDB IDs		6IRS 6IRT 6JMQ	2DH2 2DH3 6IRS 6IRT 6JMQ 6JMR 6S8V
Enriched GO Terms of Interacting Partners?
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