SLC3A2 and ICAM1

Data Source:
HPRD (in vivo)

		SLC3A2	ICAM1
Description		solute carrier family 3 member 2	intercellular adhesion molecule 1
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GO Annotations	Cellular Component	Nucleoplasm Lysosomal Membrane Plasma Membrane Basal Plasma Membrane Cell Surface Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cell Junction Melanosome Extracellular Exosome Amino Acid Transport Complex	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Membrane Raft Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding Double-stranded RNA Binding Catalytic Activity Calcium:sodium Antiporter Activity Protein Binding Aromatic Amino Acid Transmembrane Transporter Activity Neutral Amino Acid Transmembrane Transporter Activity L-alanine Transmembrane Transporter Activity L-leucine Transmembrane Transporter Activity Cadherin Binding	Virus Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding Signaling Receptor Activity
	Biological Process	Carbohydrate Metabolic Process Calcium Ion Transport Amino Acid Transport Phenylalanine Transport Tryptophan Transport Sodium Ion Transmembrane Transport Response To Exogenous DsRNA Leukocyte Migration Leucine Import Across Plasma Membrane L-alpha-amino Acid Transmembrane Transport L-leucine Import Across Plasma Membrane L-alanine Import Across Plasma Membrane	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Ionizing Radiation Response To Sulfur Dioxide Cytokine-mediated Signaling Pathway Membrane To Membrane Docking Extracellular Matrix Organization Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Response To Insulin Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Drug Response To Amino Acid Positive Regulation Of GTPase Activity Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Viral Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Cellular Response To Dexamethasone Stimulus T Cell Extravasation Establishment Of Endothelial Intestinal Barrier Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cellular Response To Amyloid-beta Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Basigin interactions Amino acid transport across the plasma membrane Defective SLC7A7 causes lysinuric protein intolerance (LPI) Tryptophan catabolism	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling
Drugs			Natalizumab Hyaluronic acid Nafamostat
Diseases			Allograft rejection
GWAS		Iron status biomarkers (transferrin saturation) ( 28334935)	Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 21102463) Height ( 31562340) Inflammatory bowel disease ( 23128233) Low white blood cell count (conditioned on rs2814778) ( 29596498) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) Pulse pressure ( 27841878) Soluble ICAM-1 ( 21533024 31217265 18604267) White blood cell count ( 32888494)
Interacting Genes		16 interacting genes: CCR4 EBP EGFR GPR37 HNRNPD ICAM1 ITGB1 MTNR1B NPSR1 SLC7A10 SLC7A11 SLC7A5 SLC7A7 SLC7A8 TLCD3A VHL	16 interacting genes: CYSRT1 EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 KEAP1 KRTAP10-8 MSN SLC3A2 SPN UBQLN2
Entrez ID		6520	3383
HPRD ID		01148	00996
Ensembl ID		ENSG00000168003	ENSG00000090339
Uniprot IDs		J3KPF3 P08195	A0A384MEK5 P05362
PDB IDs		2DH2 2DH3 6IRS 6IRT 6JMQ 6JMR 6S8V	1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX 5MZA 6EIT 6S8U
Enriched GO Terms of Interacting Partners?
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