ACTN4 and ATXN7

Data Source:
BioGRID (two hybrid)

		ACTN4	ATXN7
Description		actinin alpha 4	ataxin 7
Image
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Nuclear Body Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Ion Channel Binding Protein N-terminus Binding Actin Filament Binding	Protein Binding
	Biological Process	Response To Hypoxia Platelet Degranulation Protein Transport Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination
Pathways		Platelet degranulation Nephrin family interactions	HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis	Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Brain morphology (MOSTest) ( 32665545) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)
Interacting Genes		55 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	59 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF
Entrez ID		81	6314
HPRD ID		05222	06365
Ensembl ID		ENSG00000130402	ENSG00000163635
Uniprot IDs		A0A0S2Z3G9 O43707	O15265 Q9UPD8
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6	2KKR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?