ATXN7 and AGRN

Data Source:
BioGRID (two hybrid)

		ATXN7	AGRN
Description		ataxin 7	agrin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Extracellular Region Basement Membrane Golgi Lumen Plasma Membrane Integral Component Of Membrane Lysosomal Lumen Synapse Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding	Dystroglycan Binding Structural Constituent Of Cytoskeleton Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding Sialic Acid Binding Chondroitin Sulfate Binding Laminin Binding Heparan Sulfate Proteoglycan Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination	Retinoid Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Cytoskeleton Organization Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Neuromuscular Junction Development Animal Organ Morphogenesis Tissue Development Extracellular Matrix Organization Receptor Clustering Positive Regulation Of GTPase Activity Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Synaptic Growth At Neuromuscular Junction Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Positive Regulation Of Filopodium Assembly
Pathways		HATs acetylate histones Ub-specific processing proteases	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS NCAM1 interactions Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Congenital myasthenic syndrome
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)
Interacting Genes		59 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	9 interacting genes: ATN1 ATXN7 BOLL CACNA1A DAG1 GFI1B MAGED1 TEPSIN UBC
Entrez ID		6314	375790
HPRD ID		06365	10550
Ensembl ID		ENSG00000163635	ENSG00000188157
Uniprot IDs		O15265 Q9UPD8	O00468
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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