ACTN4 and USP6NL

Data Source:
HPRD (in vivo, in vitro)

		ACTN4	USP6NL
Description		actinin alpha 4	USP6 N-terminal like
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Nuclear Body Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Neuron Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex	Cytosol Plasma Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Nuclear Hormone Receptor Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Ion Channel Binding Protein N-terminus Binding Actin Filament Binding	GTPase Activator Activity Small GTPase Binding
	Biological Process	Response To Hypoxia Platelet Degranulation Protein Transport Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription	Intracellular Protein Transport Golgi Organization Virion Assembly Retrograde Transport, Plasma Membrane To Golgi Positive Regulation Of GTPase Activity Plasma Membrane To Endosome Transport Activation Of GTPase Activity Regulation Of Cilium Assembly Regulation Of Golgi Organization
Pathways		Platelet degranulation Nephrin family interactions	Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS		Brain morphology (MOSTest) ( 32665545) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	Alzheimer's disease ( 28183528) Alzheimer's disease in APOE e4- carriers ( 25778476) Obesity-related traits ( 23251661)
Interacting Genes		55 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	6 interacting genes: ACTA1 ACTN4 APP EPS8 GRB2 RAB5A
Entrez ID		81	9712
HPRD ID		05222	08957
Ensembl ID		ENSG00000130402	ENSG00000148429
Uniprot IDs		A0A0S2Z3G9 O43707	Q92738 X6RAB3
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?
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