STK33 and HPD

Data Source:
BioGRID (enzymatic study)

		STK33	HPD
Description		serine/threonine kinase 33	4-hydroxyphenylpyruvate dioxygenase
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Extracellular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	4-hydroxyphenylpyruvate Dioxygenase Activity Metal Ion Binding
	Biological Process	Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Protein Autophosphorylation	L-phenylalanine Catabolic Process Tyrosine Catabolic Process
Pathways			Tyrosine catabolism
Drugs		Fostamatinib	Nitisinone DAS869
Diseases			Tyrosinemia; Tyrosinemia, type I; Tyrosinemia, type II; Tyrosinemia, type III; Hawkinsinuria
GWAS		Adult body size ( 32376654) Body mass index ( 26426971 19079261 28892062 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Fruit consumption ( 32066663) Intake of total sugars ( 31005972) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Small cell lung carcinoma ( 28604730)	HDL cholesterol levels ( 32203549) Obesity-related traits ( 23251661) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407 21572414)
Interacting Genes		5 interacting genes: APP GLYCTK HPD USP15 USP5	5 interacting genes: CDKN1A HIVEP1 IKBKG RIDA STK33
Entrez ID		65975	3242
HPRD ID		09642	02041
Ensembl ID		ENSG00000130413	ENSG00000158104
Uniprot IDs		B3KS39 B4DDH2 F8WAK5 Q9BYT3	P32754
PDB IDs			3ISQ 5EC3
Enriched GO Terms of Interacting Partners?
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