STK33 and USP5

Data Source:
BioGRID (pull down)

		STK33	USP5
Description		serine/threonine kinase 33	ubiquitin specific peptidase 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Perinuclear Region Of Cytoplasm	Nucleus Lysosome Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Ubiquitin Binding
	Biological Process	Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Protein Autophosphorylation	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination
Pathways			Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs		Fostamatinib
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 26426971 19079261 28892062 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Fruit consumption ( 32066663) Intake of total sugars ( 31005972) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Small cell lung carcinoma ( 28604730)	Refractive error ( 32231278)
Interacting Genes		5 interacting genes: APP GLYCTK HPD USP15 USP5	26 interacting genes: APP DAZAP2 DVL2 PJA1 PLA2G2A RFFL RNF11 RNF216 SMURF1 SPART STK33 SUMO2 TADA3 TMEM239 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIML1 UBC UBE2S UBTD2 USP28
Entrez ID		65975	8078
HPRD ID		09642	03265
Ensembl ID		ENSG00000130413	ENSG00000111667
Uniprot IDs		B3KS39 B4DDH2 F8WAK5 Q9BYT3	A0A140VJZ1 P45974
PDB IDs			2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G
Enriched GO Terms of Interacting Partners?
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