CYB5B and MARCHF8

Data Source:
BioGRID (two hybrid)

		CYB5B	MARCHF8
Description		cytochrome b5 type B	membrane associated ring-CH-type finger 8
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GO Annotations	Cellular Component	Mitochondrial Outer Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle Nitric-oxide Synthase Complex	Cytoplasm Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane
	Molecular Function	Protein Binding Enzyme Activator Activity Electron Transfer Activity Heme Binding Metal Ion Binding Nitrite Reductase (NO-forming) Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding MHC Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Xenobiotic Metabolic Process Nitric Oxide Biosynthetic Process Electron Transport Chain Regulation Of Catalytic Activity	Protein Polyubiquitination Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response
Pathways		Phase I - Functionalization of compounds
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Blood osmolality (transformed sodium) ( 28360221) Blood pressure (smoking interaction) ( 25189868) Body mass index ( 26426971) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Serum uric acid levels ( 30993211 29403010)
Interacting Genes		48 interacting genes: AHNAK2 APP AQP6 BIK BNIP3L BTNL9 CD33 CD79A CGRRF1 CLDN7 CLN8 CPLX4 CREB3 EBP FAM209A FAM210B FNDC9 FRMD3 GJB5 GPR152 IGSF9 KCNK5 KIR2DL3 LMNA MARCHF8 MFF MFSD14B MFSD4B MFSD5 MUC1 NDUFAF2 PDZK1IP1 PHACTR3 PLPP4 REEP4 RETREG3 SDHAF4 SLC10A6 SLC16A2 SLC39A9 STOM STX1A SYT1 TMEM139 TMEM237 TMEM35A TMEM41A TMEM86B	11 interacting genes: ARR3 CD86 CYB5B FA2H GOSR2 IL1RAP TMEM14C UBE2D1 UBE2D3 UBE2H VAMP2
Entrez ID		80777	220972
HPRD ID		13106	17466
Ensembl ID		ENSG00000103018	ENSG00000165406
Uniprot IDs		O43169	A0A024R7U2 Q5T0T0
PDB IDs		3NER	2D8S
Enriched GO Terms of Interacting Partners?
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