MARCHF8 and GOSR2

Data Source:
BioGRID (two hybrid)

		MARCHF8	GOSR2
Description		membrane associated ring-CH-type finger 8	golgi SNAP receptor complex member 2
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane SNARE Complex Late Endosome Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding MHC Protein Binding Ubiquitin Protein Ligase Activity	SNARE Binding SNAP Receptor Activity Protein Binding
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response	Protein Targeting To Vacuole Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport IRE1-mediated Unfolded Protein Response Retrograde Transport, Endosome To Golgi COPII Vesicle Coating Vesicle Fusion With Golgi Apparatus
Pathways			COPII-mediated vesicle transport XBP1(S) activates chaperone genes Cargo concentration in the ER COPI-mediated anterograde transport Intra-Golgi traffic
Drugs
Diseases
GWAS			Aortic root size ( 28394258) Atrial fibrillation ( 29892015) Blood pressure ( 21909110) Blood urea nitrogen levels ( 31152163 29403010) Body mass index ( 26426971) Cleft lip with or without cleft palate ( 28054174) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Feeling guilty ( 29500382) Feeling worry ( 29500382) Hemoglobin levels ( 32327693) Idiopathic pulmonary fibrosis ( 29066090) Ischemic stroke ( 29930801) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Myocardial infarction ( 30226566) Nonsyndromic cleft lip with cleft palate ( 28232668) Orofacial clefts ( 28054174) Pulse pressure ( 27841878 28739976 30578418) QRS duration ( 27577874 30012220 21076409) QT interval ( 29874175) Systolic blood pressure ( 28135244 27841878 21909115 28739976 27618447 27618452 30578418)
Interacting Genes		11 interacting genes: ARR3 CD86 CYB5B FA2H GOSR2 IL1RAP TMEM14C UBE2D1 UBE2D3 UBE2H VAMP2	51 interacting genes: APP AQP6 ARF1 ARL13B BET1 BLCAP CREB3L1 CYB561 CYBRD1 EBP ELOVL4 ELOVL5 FAM174A FAM209A FATE1 GOLGA8EP GOLGA8F GPR152 GPR42 GPX8 HIBADH HSD17B13 IER3IP1 JAGN1 KASH5 LEUTX LIME1 LMNA MARCHF8 MFF MFSD14B MFSD5 NAPA PELI1 RETREG3 RIC3 RNF19B SLC10A1 SLC10A6 SPAG4 STX1A STX4 STX5 TLCD4 TM4SF19 TMCO5A TMEM106A TMEM106C TMEM205 TMEM35A USO1
Entrez ID		220972	9570
HPRD ID		17466	04937
Ensembl ID		ENSG00000165406	ENSG00000108433
Uniprot IDs		A0A024R7U2 Q5T0T0	A0A1W2PQE0 A0A1W2PQM3 A0A1W2PR02 A0A1W2PRL0 I3NI02 O14653
PDB IDs		2D8S	3EG9
Enriched GO Terms of Interacting Partners?
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