MARCHF8 and IL1RAP

Data Source:
BioGRID (enzymatic study)

		MARCHF8	IL1RAP
Description		membrane associated ring-CH-type finger 8	interleukin 1 receptor accessory protein
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GO Annotations	Cellular Component	Cytoplasm Lysosome Lysosomal Membrane Endosome Integral Component Of Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Late Endosome Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Glutamatergic Synapse
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding MHC Protein Binding Ubiquitin Protein Ligase Activity	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Interleukin-1 Receptor Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Protein Polyubiquitination Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Immune Response	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Positive Regulation Of Interleukin-6 Production Interleukin-33-mediated Signaling Pathway Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly
Pathways
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488 28240269) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)
Interacting Genes		11 interacting genes: ARR3 CD86 CYB5B FA2H GOSR2 IL1RAP TMEM14C UBE2D1 UBE2D3 UBE2H VAMP2	20 interacting genes: CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		220972	3556
HPRD ID		17466	04021
Ensembl ID		ENSG00000165406	ENSG00000196083
Uniprot IDs		A0A024R7U2 Q5T0T0	A8K6K4 Q9NPH3
PDB IDs		2D8S	3O4O 4DEP
Enriched GO Terms of Interacting Partners?
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