STAM and PMEPA1

Data Source:
BioGRID (pull down)

		STAM	PMEPA1
Description		signal transducing adaptor molecule	prostate transmembrane protein, androgen induced 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Early Endosome Membrane ESCRT-0 Complex Intracellular Membrane-bounded Organelle	Golgi Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ubiquitin-like Protein Ligase Binding	Protein Binding WW Domain Binding R-SMAD Binding
	Biological Process	Signal Transduction Endosomal Transport Macroautophagy Protein Deubiquitination Multivesicular Body Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Membrane Organization Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly	Negative Regulation Of SMAD Protein Complex Assembly Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Pathways		EGFR downregulation Metalloprotease DUBs Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell Endosomal Sorting Complex Required For Transport (ESCRT)	Downregulation of TGF-beta receptor signaling
Drugs
Diseases
GWAS			Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Response to fenofibrate (adiponectin levels) ( 23149075)
Interacting Genes		20 interacting genes: ARRB1 HGS JAK1 JAK2 JAK3 MAP3K1 PJA1 PMEPA1 PPP1CA PPP1CC RFFL STAMBP TIMM8A TRIM54 TRIM55 TRIM63 UBC USP15 USP28 USP8	11 interacting genes: DCTN5 DCTN6 EPN2 HGS NEDD4 OTUB2 SGTA STAM UBASH3A UBQLN2 UBQLN4
Entrez ID		8027	56937
HPRD ID		03542	09415
Ensembl ID		ENSG00000136738	ENSG00000124225
Uniprot IDs		B4DZT2 Q92783	Q5JY37 Q969W9
PDB IDs		2L0A 3F1I 3LDZ
Enriched GO Terms of Interacting Partners?
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