RUFY1 and BMX

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, enzymatic study)
HPRD (two hybrid, in vivo)

		RUFY1	BMX
Description		RUN and FYVE domain containing 1	BMX non-receptor tyrosine kinase
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GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Nuclear Speck Early Endosome Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Cytosol Plasma Membrane Ruffle Membrane
	Molecular Function	Protein Binding Lipid Binding SH3 Domain Binding SH2 Domain Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Endocytosis Small GTPase Mediated Signal Transduction Protein Transport Regulation Of Endocytosis	Adaptive Immune Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation B Cell Receptor Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane	Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Daytime sleep phenotypes ( 27126917) Dental caries (decayed and filled deciduous teeth) ( 31533690) Eating disorders ( 22911880) Lung cancer ( 28604730) Monocyte percentage of white cells ( 32888494) TPE interval (resting) ( 32386560)
Interacting Genes		18 interacting genes: AP3B2 AP3D1 AP3M1 AP3S1 BMX EPHA3 GIT2 ITSN2 OAS1 PIAS2 RAB14 RAB39B RAB3IP RAB4A RAB5A TRIM23 TXNDC17 UTP25	26 interacting genes: APP BCAR1 BIRC2 BTK CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR NOPCHAP1 PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B
Entrez ID		80230	660
HPRD ID		15282	02111
Ensembl ID		ENSG00000176783	ENSG00000102010
Uniprot IDs		A8K7B1 Q96T51	P51813
PDB IDs		2YQM 2YW8	2EKX 2YS2 3SXR 3SXS 6I99
Enriched GO Terms of Interacting Partners?
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