ORAI2 and MED31

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ORAI2	MED31
Description		ORAI calcium release-activated calcium modulator 2	mediator complex subunit 31
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane Growth Cone	Ubiquitin Ligase Complex Nucleoplasm Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding Store-operated Calcium Channel Activity	Transcription Coregulator Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Store-operated Calcium Entry Calcium Ion Transmembrane Transport	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Negative Regulation Of Fibroblast Proliferation Limb Development
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Chronotype ( 30696823 27494321) Morning vs. evening chronotype ( 27494321)	LDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883)
Interacting Genes		5 interacting genes: COPS6 GDF9 MED31 SETDB1 UNC119	59 interacting genes: AGR2 ANXA7 ASCC2 CACNB4 CCT7 CDKN1A CPE DAZAP2 DLEU1 DNM1 EEF1G EGR2 EPN1 ERH FAM118B GADD45G GSTM4 HGH1 HMOX2 HNRNPUL1 HSPB1 HSPB3 HTT LAMA4 LYPLA2 MAFG MED18 MED19 MED7 MED8 MED9 MOB4 NAF1 NFATC2 NR4A1 ORAI2 PABPC4 PAFAH1B3 PFDN1 PMF1 PQBP1 PRMT1 PSMD11 RAB25 RBM23 RFC5 RPA2 SAT1 SELENBP1 SERPINB9 SMN1 TGIF1 TINAGL1 TK1 TLE5 UBE2B WDCP ZBTB45 ZSCAN1
Entrez ID		80228	51003
HPRD ID		09860	14382
Ensembl ID		ENSG00000160991	ENSG00000108590
Uniprot IDs		B4DUB4 Q96SN7	Q9Y3C7
PDB IDs
Enriched GO Terms of Interacting Partners?
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