ORAI2 and UNC119

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ORAI2	UNC119
Description		ORAI calcium release-activated calcium modulator 2	unc-119 lipid binding chaperone
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Integral Component Of Membrane Growth Cone	Spindle Pole Centrosome Cytosol Intercellular Bridge Synapse Spindle Midzone
	Molecular Function	Protein Binding Store-operated Calcium Channel Activity	Protein Binding Lipid Binding
	Biological Process	Store-operated Calcium Entry Calcium Ion Transmembrane Transport	Mitotic Cytokinesis Endocytosis Chemical Synaptic Transmission Nervous System Development Visual Perception Phototransduction Lipoprotein Transport Positive Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Caveolin-mediated Endocytosis
Pathways		Elevation of cytosolic Ca2+ levels Ion homeostasis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Chronotype ( 30696823 27494321) Morning vs. evening chronotype ( 27494321)
Interacting Genes		5 interacting genes: COPS6 GDF9 MED31 SETDB1 UNC119	103 interacting genes: AAGAB ALDH2 AMOT ANKRD24 ANXA1 ANXA3 ANXA7 ARL15 ARL2 ARL3 ARL4D ASH2L BCR BRIX1 BTBD2 C16orf74 CBX8 CCL18 CD247 CD3E CD4 CDC42 CDKN1A CDKN2C CETN3 CKMT2 CKS2 COX17 CYB561D2 EIF2S2 ERH FKBPL FXYD6 FYN GIPC2 GSTM4 HCK HLA-DQA1 HMGB1 HSPB3 HSPE1 ID2 IL5RA ITSN1 KDM1A KRTAP1-3 KRTAP9-3 KRTAP9-8 LAMA4 LCK LIG4 LRIF1 LUC7L2 LYN MAP3K20 MAPK10 MAPK8IP2 MPHOSPH6 MRPS12 ORAI2 PAFAH1B3 PAPSS1 PCDHA4 PFN1 PHF10 PIN1 PLPP2 PPA1 PPP3CA PPP3CC PSMD11 PSMD2 PTPRS QTRT1 RAP1B RASSF6 RBPMS2 RCAN3 RCC1 RFC5 RGL2 RPA2 RPS6KA5 RUFY3 S100A4 S100A8 SAT1 SEPHS1 SERPINB9 SMN1 SULT1E1 TK1 TMEM200A TP53BP2 TP53I3 TP53INP1 TRDMT1 TSC22D1 UBE2B UBE2I UBQLN4 ZFP64 ZNF24
Entrez ID		80228	9094
HPRD ID		09860	04927
Ensembl ID		ENSG00000160991	ENSG00000109103
Uniprot IDs		B4DUB4 Q96SN7	K7EN86 Q13432
PDB IDs			3GQQ 3RBQ 4GOJ 4GOK 5L7K 6H6A
Enriched GO Terms of Interacting Partners?
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