RAB11FIP1 and RFFL

Data Source:
BioGRID (enzymatic study)

		RAB11FIP1	RFFL
Description		RAB11 family interacting protein 1	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Cytosol Phagocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane
	Molecular Function		Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Transport Regulated Exocytosis Negative Regulation Of Adiponectin Secretion	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways			Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Axial length ( 24144296)	Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		5 interacting genes: RAB11A RAB11B RAB25 RAB4A RFFL	21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		80223	117584
HPRD ID		09787	11489
Ensembl ID		ENSG00000156675	ENSG00000092871
Uniprot IDs		Q6WKZ4	Q8WZ73
PDB IDs		4D0G	1Y02
Enriched GO Terms of Interacting Partners?
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