TMEM134 and CLN8

Data Source:
BioGRID (two hybrid)

		TMEM134	CLN8
Description		transmembrane protein 134	CLN8 transmembrane ER and ERGIC protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Presynapse
	Molecular Function	Protein Binding	Protein Binding Ceramide Binding
	Biological Process	Viral Process	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Glutamate Reuptake Lipid Homeostasis Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization
Pathways
Drugs
Diseases			Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10) Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Refractive error ( 32231278)	Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		6 interacting genes: CLN8 ERBB2 ERBB3 ERBB4 SLC22A2 VKORC1	30 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 FZD7 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUP1
Entrez ID		80194	2055
HPRD ID		08642	06383
Ensembl ID		ENSG00000172663	ENSG00000182372
Uniprot IDs		Q9H6X4	A0A024QZ57 Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?
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